Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

Abstract Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multip...

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Bibliographic Details
Main Authors: Johanna M. Johansson, Hampus Du Rietz, Hampus Hedlund, Hanna C. Eriksson, Erik Oude Blenke, Aditya Pote, Said Harun, Pontus Nordenfelt, Lennart Lindfors, Anders Wittrup
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60959-z
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