“Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks”
Abstract High arsenic (As) exposure (≥ 100 µg/l) is associated with cardiovascular (CVD) outcomes, however, the CVD risk from low-to-moderate As exposure (< 100 µg/l) has been less explored. There is a paucity of systematic reviews that comprehensively evaluate both urine and water As exposure me...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Environmental Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12940-025-01184-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850277969307631616 |
|---|---|
| author | Meroona Gopang Mahdieh Danesh Yazdi Anne Moyer Dylan M. Smith Jaymie R. Meliker |
| author_facet | Meroona Gopang Mahdieh Danesh Yazdi Anne Moyer Dylan M. Smith Jaymie R. Meliker |
| author_sort | Meroona Gopang |
| collection | DOAJ |
| description | Abstract High arsenic (As) exposure (≥ 100 µg/l) is associated with cardiovascular (CVD) outcomes, however, the CVD risk from low-to-moderate As exposure (< 100 µg/l) has been less explored. There is a paucity of systematic reviews that comprehensively evaluate both urine and water As exposure metrics in assessing As-related CVD outcomes within the general population. To fill this gap, this review sought to update and consolidate data regarding the correlation between low-to-moderate As exposure and specific CVD outcomes, including stroke, ischemic heart disease (IHD), acute myocardial infarction (AMI), and heart failure (HF). A search for peer-reviewed articles indexed in PubMed, Embase, CINAHL, the Global Medicos Index, and Web of Science and unpublished dissertations in Prospero until October 31, 2024, was performed. Nineteen studies were included. Relative risks were pooled by contrasting the highest v/s lowest exposure groups across studies. Positive associations were observed between urine As and stroke incidence, and water As with IHD incidence. Associations between water As and IHD and AMI mortality were suggestive and became stronger after excluding ecological studies. Sex-stratified analyses suggested an increased risk for all groups with strongest indication of an increased risk of AMI mortality in men. Increased risk was suggested for HF but only two studies assessed this outcome. These findings underscore potential risk for CVD outcomes in relation to low-to-moderate As exposure, and highlight the necessity for additional rigorous, well-structured studies to more clearly delineate the possible effects of low-to-moderate As exposure on different CVD outcomes. |
| format | Article |
| id | doaj-art-15b3dbfd57ec45d299ae6fa95c8c75a7 |
| institution | OA Journals |
| issn | 1476-069X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj-art-15b3dbfd57ec45d299ae6fa95c8c75a72025-08-20T01:49:40ZengBMCEnvironmental Health1476-069X2025-05-0124111210.1186/s12940-025-01184-5“Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks”Meroona Gopang0Mahdieh Danesh Yazdi1Anne Moyer2Dylan M. Smith3Jaymie R. Meliker4Program of Public Health, Stony Brook UniversityProgram of Public Health, Stony Brook UniversityDepartment of Psychology, Stony Brook UniversityProgram of Public Health, Stony Brook UniversityProgram of Public Health, Stony Brook UniversityAbstract High arsenic (As) exposure (≥ 100 µg/l) is associated with cardiovascular (CVD) outcomes, however, the CVD risk from low-to-moderate As exposure (< 100 µg/l) has been less explored. There is a paucity of systematic reviews that comprehensively evaluate both urine and water As exposure metrics in assessing As-related CVD outcomes within the general population. To fill this gap, this review sought to update and consolidate data regarding the correlation between low-to-moderate As exposure and specific CVD outcomes, including stroke, ischemic heart disease (IHD), acute myocardial infarction (AMI), and heart failure (HF). A search for peer-reviewed articles indexed in PubMed, Embase, CINAHL, the Global Medicos Index, and Web of Science and unpublished dissertations in Prospero until October 31, 2024, was performed. Nineteen studies were included. Relative risks were pooled by contrasting the highest v/s lowest exposure groups across studies. Positive associations were observed between urine As and stroke incidence, and water As with IHD incidence. Associations between water As and IHD and AMI mortality were suggestive and became stronger after excluding ecological studies. Sex-stratified analyses suggested an increased risk for all groups with strongest indication of an increased risk of AMI mortality in men. Increased risk was suggested for HF but only two studies assessed this outcome. These findings underscore potential risk for CVD outcomes in relation to low-to-moderate As exposure, and highlight the necessity for additional rigorous, well-structured studies to more clearly delineate the possible effects of low-to-moderate As exposure on different CVD outcomes.https://doi.org/10.1186/s12940-025-01184-5ArsenicCardiovascular diseaseStrokeAcute Myocardial InfarctionIschemic Heart DiseaseHeart Failure |
| spellingShingle | Meroona Gopang Mahdieh Danesh Yazdi Anne Moyer Dylan M. Smith Jaymie R. Meliker “Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks” Environmental Health Arsenic Cardiovascular disease Stroke Acute Myocardial Infarction Ischemic Heart Disease Heart Failure |
| title | “Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks” |
| title_full | “Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks” |
| title_fullStr | “Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks” |
| title_full_unstemmed | “Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks” |
| title_short | “Low-to-moderate arsenic exposure: a global systematic review of cardiovascular disease risks” |
| title_sort | low to moderate arsenic exposure a global systematic review of cardiovascular disease risks |
| topic | Arsenic Cardiovascular disease Stroke Acute Myocardial Infarction Ischemic Heart Disease Heart Failure |
| url | https://doi.org/10.1186/s12940-025-01184-5 |
| work_keys_str_mv | AT meroonagopang lowtomoderatearsenicexposureaglobalsystematicreviewofcardiovasculardiseaserisks AT mahdiehdaneshyazdi lowtomoderatearsenicexposureaglobalsystematicreviewofcardiovasculardiseaserisks AT annemoyer lowtomoderatearsenicexposureaglobalsystematicreviewofcardiovasculardiseaserisks AT dylanmsmith lowtomoderatearsenicexposureaglobalsystematicreviewofcardiovasculardiseaserisks AT jaymiermeliker lowtomoderatearsenicexposureaglobalsystematicreviewofcardiovasculardiseaserisks |