Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment

The infection of the orbita and ocular tissues can result in severe local and systemic complications. We aimed to determine the predisposing factors for preseptal and orbital cellulitis, the clinical and routine laboratory differences between orbital and preseptal cellulitis, and the change i...

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Main Authors: Ilker Devrim, Güler Kanra, Ateş Kara, A Bülent Cengiz, Mehmet Orhan, Mehmet Ceyhan, Gülten Seçmeer
Format: Article
Language:English
Published: Hacettepe University Institute of Child Health 2008-06-01
Series:The Turkish Journal of Pediatrics
Online Access:https://turkjpediatr.org/article/view/2417
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author Ilker Devrim
Güler Kanra
Ateş Kara
A Bülent Cengiz
Mehmet Orhan
Mehmet Ceyhan
Gülten Seçmeer
author_facet Ilker Devrim
Güler Kanra
Ateş Kara
A Bülent Cengiz
Mehmet Orhan
Mehmet Ceyhan
Gülten Seçmeer
author_sort Ilker Devrim
collection DOAJ
description The infection of the orbita and ocular tissues can result in severe local and systemic complications. We aimed to determine the predisposing factors for preseptal and orbital cellulitis, the clinical and routine laboratory differences between orbital and preseptal cellulitis, and the change in the spectrum of the pathogens and the antibiotics used in the last 10 years. One hundred thirty-nine patients, hospitalized in Hacettepe University Faculty of Medicine Children's Hospital between 1 January 1990 and 31 December 2003 with diagnosis ofperiorbital or orbital cellulitis, were reviewed retrospectively. Ten of the patients (7%) had orbital and 129 (93%) had preseptal cellulitis. The male/female ratio was 1.7:1. The average age (mean+/-standard deviation) was 5.7+/-4 years. The seasonal distribution was most marked in spring and fall periods. When compared with preseptal cellulitis, the mean blood cell count, erythrocyte sedimentation rate and C-reactive protein levels were significantly higher in patients with orbital cellulitis. Staphylococcus aureus was isolated in 13 (41.9% of total microbiologically confirmed cases), coagulase-negative staphylococcus in 8 (25.8%), and H. influenza type b in 2 patients (6%). Thirty out of 77 clinical sample cultures (39%) were positive. In clinical studies, etiological agents of orbital and preseptal cellulitis could be identified in only 20-30% of cases, so in clinical practice treatment is usually empiric. We observed that sulbactam-ampicillin was a safe and effective choice of treatment in orbital and preseptal cellulitis in our cases.
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publishDate 2008-06-01
publisher Hacettepe University Institute of Child Health
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series The Turkish Journal of Pediatrics
spelling doaj-art-15ad52b7b97443d4819cdf04faa782dd2025-08-20T02:01:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212008-06-01503Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatmentIlker Devrim0Güler KanraAteş KaraA Bülent CengizMehmet OrhanMehmet CeyhanGülten SeçmeerDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. The infection of the orbita and ocular tissues can result in severe local and systemic complications. We aimed to determine the predisposing factors for preseptal and orbital cellulitis, the clinical and routine laboratory differences between orbital and preseptal cellulitis, and the change in the spectrum of the pathogens and the antibiotics used in the last 10 years. One hundred thirty-nine patients, hospitalized in Hacettepe University Faculty of Medicine Children's Hospital between 1 January 1990 and 31 December 2003 with diagnosis ofperiorbital or orbital cellulitis, were reviewed retrospectively. Ten of the patients (7%) had orbital and 129 (93%) had preseptal cellulitis. The male/female ratio was 1.7:1. The average age (mean+/-standard deviation) was 5.7+/-4 years. The seasonal distribution was most marked in spring and fall periods. When compared with preseptal cellulitis, the mean blood cell count, erythrocyte sedimentation rate and C-reactive protein levels were significantly higher in patients with orbital cellulitis. Staphylococcus aureus was isolated in 13 (41.9% of total microbiologically confirmed cases), coagulase-negative staphylococcus in 8 (25.8%), and H. influenza type b in 2 patients (6%). Thirty out of 77 clinical sample cultures (39%) were positive. In clinical studies, etiological agents of orbital and preseptal cellulitis could be identified in only 20-30% of cases, so in clinical practice treatment is usually empiric. We observed that sulbactam-ampicillin was a safe and effective choice of treatment in orbital and preseptal cellulitis in our cases. https://turkjpediatr.org/article/view/2417
spellingShingle Ilker Devrim
Güler Kanra
Ateş Kara
A Bülent Cengiz
Mehmet Orhan
Mehmet Ceyhan
Gülten Seçmeer
Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment
The Turkish Journal of Pediatrics
title Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment
title_full Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment
title_fullStr Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment
title_full_unstemmed Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment
title_short Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment
title_sort preseptal and orbital cellulitis 15 year experience with sulbactam ampicillin treatment
url https://turkjpediatr.org/article/view/2417
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