Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases
Abstract Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical and economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types and offer strong regenerati...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-025-04167-y |
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| _version_ | 1850196963939581952 |
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| author | Haiming Li Peng Zhang Minghui Lin Kang Li Cunxin Zhang Xiao He Kai Gao |
| author_facet | Haiming Li Peng Zhang Minghui Lin Kang Li Cunxin Zhang Xiao He Kai Gao |
| author_sort | Haiming Li |
| collection | DOAJ |
| description | Abstract Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical and economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types and offer strong regenerative potential, making them promising for treating various diseases. However, issues with the immune response and cell survival limit the effectiveness of cell transplantation. This has led to increased interest in cell-free stem cell therapy, particularly the use of exosomes, which is the most studied form of this approach. Exosomes are extracellular vesicles that contain proteins, lipids, and nucleic acids and play a key role in cell communication and material exchange. Pyroptosis, a form of cell death involved in innate immunity, is also associated with many diseases. Studies have shown that MSC-derived exosomes have therapeutic potential for treating a range of conditions by regulating inflammation and pyroptosis. This study explored the role of MSC-derived exosomes in modulating pyroptosis to improve the treatment of bone-related diseases. |
| format | Article |
| id | doaj-art-15abcafd8df040f0b4ff0e2f284eb999 |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-15abcafd8df040f0b4ff0e2f284eb9992025-08-20T02:13:19ZengBMCStem Cell Research & Therapy1757-65122025-02-0116112010.1186/s13287-025-04167-yPyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseasesHaiming Li0Peng Zhang1Minghui Lin2Kang Li3Cunxin Zhang4Xiao He5Kai Gao6Shandong University of Traditional Chinese MedicineDepartment of OrthopaedicsShandong University of Traditional Chinese MedicineDepartment of Spine SurgeryDepartment of Spine SurgeryDepartment of OrthopaedicsShandong University of Traditional Chinese MedicineAbstract Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical and economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types and offer strong regenerative potential, making them promising for treating various diseases. However, issues with the immune response and cell survival limit the effectiveness of cell transplantation. This has led to increased interest in cell-free stem cell therapy, particularly the use of exosomes, which is the most studied form of this approach. Exosomes are extracellular vesicles that contain proteins, lipids, and nucleic acids and play a key role in cell communication and material exchange. Pyroptosis, a form of cell death involved in innate immunity, is also associated with many diseases. Studies have shown that MSC-derived exosomes have therapeutic potential for treating a range of conditions by regulating inflammation and pyroptosis. This study explored the role of MSC-derived exosomes in modulating pyroptosis to improve the treatment of bone-related diseases.https://doi.org/10.1186/s13287-025-04167-yPyroptosisMesenchymal stem cellsExosomesOsteoarthritisSpinal cord injuryDisc herniation |
| spellingShingle | Haiming Li Peng Zhang Minghui Lin Kang Li Cunxin Zhang Xiao He Kai Gao Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases Stem Cell Research & Therapy Pyroptosis Mesenchymal stem cells Exosomes Osteoarthritis Spinal cord injury Disc herniation |
| title | Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases |
| title_full | Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases |
| title_fullStr | Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases |
| title_full_unstemmed | Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases |
| title_short | Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases |
| title_sort | pyroptosis candidate key targets for mesenchymal stem cell derived exosomes for the treatment of bone related diseases |
| topic | Pyroptosis Mesenchymal stem cells Exosomes Osteoarthritis Spinal cord injury Disc herniation |
| url | https://doi.org/10.1186/s13287-025-04167-y |
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