Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey
Although complexes of the paramagnetic Gd(III) ion have been used with great success for the past 40 years to enhance image contrast in magnetic resonance imaging (MRI), important challenges such as improving the relaxation efficacy, the specificity, the safety, and the environmental impact of these...
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Académie des sciences
2025-01-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.363/ |
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| author | Pinto, Sara Martinho Almeida Lacerda, Sara Morfin, Jean-François Aroso, Rafael Tiago Teixeira, Daniela Sofia de Sousa Garda, Zoltán Pereira, Maria Miguens Geraldes, Carlos Frederico Gusmão Campos Tóth, Éva |
| author_facet | Pinto, Sara Martinho Almeida Lacerda, Sara Morfin, Jean-François Aroso, Rafael Tiago Teixeira, Daniela Sofia de Sousa Garda, Zoltán Pereira, Maria Miguens Geraldes, Carlos Frederico Gusmão Campos Tóth, Éva |
| author_sort | Pinto, Sara Martinho Almeida |
| collection | DOAJ |
| description | Although complexes of the paramagnetic Gd(III) ion have been used with great success for the past 40 years to enhance image contrast in magnetic resonance imaging (MRI), important challenges such as improving the relaxation efficacy, the specificity, the safety, and the environmental impact of these agents remain in this field. Thanks to a collaborative effort between the Centre of Molecular Biophysics in Orléans, France and the Coimbra Chemistry Centre - Institute of Molecular Sciences in Coimbra, Portugal, there have been important advances in the chemistry of MRI probes. The authors have developed rigid, medium-sized, and bishydrated Gd(III) complexes specifically optimized for high-field applications with successful validation in vivo. For the specific targeting of amyloid peptides implicated in many pathologies such as Alzheimer’s disease and diabetes, they have designed benzothiazole-derivative metal chelates with detection potential in MRI, optical, and nuclear imaging modalities. The authors have gained valuable insights into the aggregation behavior of these complexes in solution and how this affects peptide binding affinity. More recently, manganese porphyrin complexes have been investigated with the objective of visualizing the tissue redox state based on the Mn(II)/Mn(III) redox switch, which can be followed not only in classical 1H detection but also in 19F MRI. |
| format | Article |
| id | doaj-art-15ab7c86272647dc956b3e077512c2e2 |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-15ab7c86272647dc956b3e077512c2e22025-02-07T13:41:33ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432025-01-0128G19511010.5802/crchim.36310.5802/crchim.363Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journeyPinto, Sara Martinho Almeida0https://orcid.org/0000-0003-3817-1182Lacerda, Sara1https://orcid.org/0000-0003-3865-4379Morfin, Jean-François2Aroso, Rafael Tiago3https://orcid.org/0000-0002-2657-9212 Teixeira, Daniela Sofia de Sousa4https://orcid.org/0000-0001-8302-9260Garda, Zoltán5https://orcid.org/0000-0002-3904-2959Pereira, Maria Miguens6https://orcid.org/0000-0003-4958-7677 Geraldes, Carlos Frederico Gusmão Campos7https://orcid.org/0000-0002-0837-8329Tóth, Éva8https://orcid.org/0000-0002-3200-6752Coimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department of the University of Coimbra, PortugalCentre de Biophysique Moléculaire, CNRS - UPR 4301, Université d’Orléans, Orléans, FranceCentre de Biophysique Moléculaire, CNRS - UPR 4301, Université d’Orléans, Orléans, FranceCoimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department of the University of Coimbra, PortugalCentre de Biophysique Moléculaire, CNRS - UPR 4301, Université d’Orléans, Orléans, France; Coimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department of the University of Coimbra, PortugalCentre de Biophysique Moléculaire, CNRS - UPR 4301, Université d’Orléans, Orléans, FranceCoimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department of the University of Coimbra, PortugalCoimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department of the University of Coimbra, PortugalCentre de Biophysique Moléculaire, CNRS - UPR 4301, Université d’Orléans, Orléans, FranceAlthough complexes of the paramagnetic Gd(III) ion have been used with great success for the past 40 years to enhance image contrast in magnetic resonance imaging (MRI), important challenges such as improving the relaxation efficacy, the specificity, the safety, and the environmental impact of these agents remain in this field. Thanks to a collaborative effort between the Centre of Molecular Biophysics in Orléans, France and the Coimbra Chemistry Centre - Institute of Molecular Sciences in Coimbra, Portugal, there have been important advances in the chemistry of MRI probes. The authors have developed rigid, medium-sized, and bishydrated Gd(III) complexes specifically optimized for high-field applications with successful validation in vivo. For the specific targeting of amyloid peptides implicated in many pathologies such as Alzheimer’s disease and diabetes, they have designed benzothiazole-derivative metal chelates with detection potential in MRI, optical, and nuclear imaging modalities. The authors have gained valuable insights into the aggregation behavior of these complexes in solution and how this affects peptide binding affinity. More recently, manganese porphyrin complexes have been investigated with the objective of visualizing the tissue redox state based on the Mn(II)/Mn(III) redox switch, which can be followed not only in classical 1H detection but also in 19F MRI.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.363/Magnetic resonance imagingContrast agentsLanthanideManganesePorphyrins |
| spellingShingle | Pinto, Sara Martinho Almeida Lacerda, Sara Morfin, Jean-François Aroso, Rafael Tiago Teixeira, Daniela Sofia de Sousa Garda, Zoltán Pereira, Maria Miguens Geraldes, Carlos Frederico Gusmão Campos Tóth, Éva Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey Comptes Rendus. Chimie Magnetic resonance imaging Contrast agents Lanthanide Manganese Porphyrins |
| title | Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey |
| title_full | Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey |
| title_fullStr | Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey |
| title_full_unstemmed | Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey |
| title_short | Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey |
| title_sort | towards more efficient more specific and safer mri contrast agents a portuguese french collaborative journey |
| topic | Magnetic resonance imaging Contrast agents Lanthanide Manganese Porphyrins |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.363/ |
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