Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease
Treatment of acute lymphoblastic leukemia (ALL) in children during the last 50 years has changed significantly, which has increased the survival of patients from 10–15 % in the early 60s to 80–85 % by the mid-2000s. Such results have been achieved through the development of new polychemotherapy regi...
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| Language: | Russian |
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ABV-press
2020-10-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/427 |
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| author | M. A. Shervashidze T. T. Valiev |
| author_facet | M. A. Shervashidze T. T. Valiev |
| author_sort | M. A. Shervashidze |
| collection | DOAJ |
| description | Treatment of acute lymphoblastic leukemia (ALL) in children during the last 50 years has changed significantly, which has increased the survival of patients from 10–15 % in the early 60s to 80–85 % by the mid-2000s. Such results have been achieved through the development of new polychemotherapy regimens, the introduction of neuroleukemia prophylaxis, the strengthening of standard chemotherapy by increasing the dose and / or frequency of chemotherapeutic drugs administration, and the definition of criteria for patient stratification into prognostic risks groups and the development of principles of risk-adopted therapy.However, inspite of the overall success of pediatric acute lymphoblastic leukemia therapy, some variants of acute lymphoblastic leukemia associated with poor prognosis, especially acute lymphoblastic leukemia with BCR-ABL1 and MLL rearrangements. Besides the prolonged persistence of minimal residual disease is also an unfavorable prognostic factor requiring therapy intensification.In the current issue we present the main steps in the evolution of programmed chemotherapy of children with acute lymphoblastic leukemia. Great attention was paid for modern risk-stratifying criteria with an emphasis on minimal residual disease. |
| format | Article |
| id | doaj-art-15a19ae3b6db4a7b97c2a6cbffb098bc |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2020-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-15a19ae3b6db4a7b97c2a6cbffb098bc2025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232020-10-01153122610.17650/1818-8346-2020-15-3-12-26355Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual diseaseM. A. Shervashidze0T. T. Valiev1Pediatric Oncology and Hematology Research Institute, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaPediatric Oncology and Hematology Research Institute, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaTreatment of acute lymphoblastic leukemia (ALL) in children during the last 50 years has changed significantly, which has increased the survival of patients from 10–15 % in the early 60s to 80–85 % by the mid-2000s. Such results have been achieved through the development of new polychemotherapy regimens, the introduction of neuroleukemia prophylaxis, the strengthening of standard chemotherapy by increasing the dose and / or frequency of chemotherapeutic drugs administration, and the definition of criteria for patient stratification into prognostic risks groups and the development of principles of risk-adopted therapy.However, inspite of the overall success of pediatric acute lymphoblastic leukemia therapy, some variants of acute lymphoblastic leukemia associated with poor prognosis, especially acute lymphoblastic leukemia with BCR-ABL1 and MLL rearrangements. Besides the prolonged persistence of minimal residual disease is also an unfavorable prognostic factor requiring therapy intensification.In the current issue we present the main steps in the evolution of programmed chemotherapy of children with acute lymphoblastic leukemia. Great attention was paid for modern risk-stratifying criteria with an emphasis on minimal residual disease.https://oncohematology.abvpress.ru/ongm/article/view/427acute lymphoblastic leukemiatreatmentminimal residual diseasechildren |
| spellingShingle | M. A. Shervashidze T. T. Valiev Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease Онкогематология acute lymphoblastic leukemia treatment minimal residual disease children |
| title | Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease |
| title_full | Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease |
| title_fullStr | Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease |
| title_full_unstemmed | Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease |
| title_short | Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease |
| title_sort | pediatric acute lymphoblastic leukemia treatment protocols improvement emphasis on minimal residual disease |
| topic | acute lymphoblastic leukemia treatment minimal residual disease children |
| url | https://oncohematology.abvpress.ru/ongm/article/view/427 |
| work_keys_str_mv | AT mashervashidze pediatricacutelymphoblasticleukemiatreatmentprotocolsimprovementemphasisonminimalresidualdisease AT ttvaliev pediatricacutelymphoblasticleukemiatreatmentprotocolsimprovementemphasisonminimalresidualdisease |