Evaluation of antihyperlipidemic effect of rosemary oil in streptozotocin-induced diabetic rats
<b>Aim: </b>In this study, the potential effects of rosemary oil on the lipid profile in streptozotocin-induced diabetic rats were examined.<p> <b>Materials and Methods:</b> In this study, thirty-two adult male Wistar Albino rats were used. Working groups were consisted...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2024-03-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1441 |
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| Summary: | <b>Aim: </b>In this study, the potential effects of rosemary oil on the lipid profile in
streptozotocin-induced diabetic rats were examined.<p>
<b>Materials and Methods:</b> In this study, thirty-two adult male Wistar Albino rats
were used. Working groups were consisted as follows: control group (C, n=6),
rosemary group (R, n=6), diabetes group (STZ, n=10) and diabetes+rosemary
group (STZ+R, n=10). The rosemary oil was administered at oral dosage of
200 mg/kg daily for duration of three weeks in the groups receiving rosemary
oil. Diabetes was performed by subcutaneous injections of streptozotocin at
dosage of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) for two consecutive days
as a single daily dose. At the end of three weeks, blood samples collected from
the all animals were assessed lipid parameters.<p>
<b>Results:</b> In this study, plasma levels of triglyceride, total cholesterol, and LDLcholesterol
significantly elevated, alongside plasma HDL-cholesterol levels in
diabetes group significantly reduced compared to the control group. However,
upon the application of rosemary oil to streptozotocin-induced diabetic rats,
a substantial decrease in plasma triglyceride, total cholesterol, and LDLcholesterol
levels was observed, while plasma HDL-cholesterol notably
increased.<p>
<b>Conclusion: </b>As a result of the current findings, it is concluded that rosemary oil
may have antihiperlipidemic properties and could be used as a phytomedicine
for the treatment of diabetes. |
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| ISSN: | 1309-6958 2146-1953 |