Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are hematological disorders affecting B cells. The clonal relationship between CLL and MM has not always been clarified, although this information is critical to understanding its pathogenesis. Here, we present a rare clinical case of sync...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2403203 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850248074236002304 |
|---|---|
| author | Jianing Zhang Ji Ma Ying Li Xiao Lv Lili Feng |
| author_facet | Jianing Zhang Ji Ma Ying Li Xiao Lv Lili Feng |
| author_sort | Jianing Zhang |
| collection | DOAJ |
| description | Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are hematological disorders affecting B cells. The clonal relationship between CLL and MM has not always been clarified, although this information is critical to understanding its pathogenesis. Here, we present a rare clinical case of synchronous CLL and MM. Whole-genome sequencing (WGS) was performed using malignant lymph node (LN) and bone marrow (BM) tissues. Based on the high consistency of single nucleotide variants (SNVs), significantly mutated genes (SMGs), copy number variations (CNVs), different B cell receptor (BCR) IGH rearrangement features in LN and BM, and the different light-chain expression patterns in CLL and MM cells, we concluded that CLL and MM cells from this patient originated from the same hematopoietic stem cell/progenitors, different pro-B cells and suffered oncogenic mutations at different B cell differentiation stages. Depth analysis of genome features using WGS provides a new method to explore the process of malignant B cell genesis. |
| format | Article |
| id | doaj-art-15984173ec3b4ece98c09544e822e93a |
| institution | OA Journals |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-15984173ec3b4ece98c09544e822e93a2025-08-20T01:58:48ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2403203Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case reportJianing Zhang0Ji Ma1Ying Li2Xiao Lv3Lili Feng4Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Hematology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Hematology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaChronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are hematological disorders affecting B cells. The clonal relationship between CLL and MM has not always been clarified, although this information is critical to understanding its pathogenesis. Here, we present a rare clinical case of synchronous CLL and MM. Whole-genome sequencing (WGS) was performed using malignant lymph node (LN) and bone marrow (BM) tissues. Based on the high consistency of single nucleotide variants (SNVs), significantly mutated genes (SMGs), copy number variations (CNVs), different B cell receptor (BCR) IGH rearrangement features in LN and BM, and the different light-chain expression patterns in CLL and MM cells, we concluded that CLL and MM cells from this patient originated from the same hematopoietic stem cell/progenitors, different pro-B cells and suffered oncogenic mutations at different B cell differentiation stages. Depth analysis of genome features using WGS provides a new method to explore the process of malignant B cell genesis.https://www.tandfonline.com/doi/10.1080/15384047.2024.2403203Chronic lymphocytic leukemiamultiple myelomawhole-genome sequencingcellular origincase report |
| spellingShingle | Jianing Zhang Ji Ma Ying Li Xiao Lv Lili Feng Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report Cancer Biology & Therapy Chronic lymphocytic leukemia multiple myeloma whole-genome sequencing cellular origin case report |
| title | Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report |
| title_full | Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report |
| title_fullStr | Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report |
| title_full_unstemmed | Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report |
| title_short | Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report |
| title_sort | whole genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma a case report |
| topic | Chronic lymphocytic leukemia multiple myeloma whole-genome sequencing cellular origin case report |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2403203 |
| work_keys_str_mv | AT jianingzhang wholegenomesequencingrevealscellularoriginofconcomitantchroniclymphocyticleukemiaandmultiplemyelomaacasereport AT jima wholegenomesequencingrevealscellularoriginofconcomitantchroniclymphocyticleukemiaandmultiplemyelomaacasereport AT yingli wholegenomesequencingrevealscellularoriginofconcomitantchroniclymphocyticleukemiaandmultiplemyelomaacasereport AT xiaolv wholegenomesequencingrevealscellularoriginofconcomitantchroniclymphocyticleukemiaandmultiplemyelomaacasereport AT lilifeng wholegenomesequencingrevealscellularoriginofconcomitantchroniclymphocyticleukemiaandmultiplemyelomaacasereport |