Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events

The canonical model of cytokine signaling via the JAK/STAT pathway dominates our view of signal transduction but provides no insight into the significance of the simultaneous presence of activated JAKs and STATs in the nucleus of cells treated with cytokines. Such a mechanistic shortcoming challenge...

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Bibliographic Details
Main Authors: Howard M. Johnson, Chulbul M. Ahmed
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2016/9564814
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