Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study
ABSTRACT Background Current evidence on relationships between serum lipid biomarkers and the risk of gastrointestinal cancers remains controversial, with no consensus reached. Methods We conducted a prospective cohort study within the Kailuan Cohort wherein 88,225 individuals with baseline informati...
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2025-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70654 |
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| author | Ying Xiao Xin Du Tianjie Wang Dong Liu Hongzhao You Hao Wang Hanyang Liang Zhengqing Ba Yilu Liu Yu Ren Jinghan Zeng Weixian Yang Shouling Wu Jiansong Yuan |
| author_facet | Ying Xiao Xin Du Tianjie Wang Dong Liu Hongzhao You Hao Wang Hanyang Liang Zhengqing Ba Yilu Liu Yu Ren Jinghan Zeng Weixian Yang Shouling Wu Jiansong Yuan |
| author_sort | Ying Xiao |
| collection | DOAJ |
| description | ABSTRACT Background Current evidence on relationships between serum lipid biomarkers and the risk of gastrointestinal cancers remains controversial, with no consensus reached. Methods We conducted a prospective cohort study within the Kailuan Cohort wherein 88,225 individuals with baseline information on triglyceride (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) was followed from 2006 to 2021 for the incidence of esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC). Cox proportional hazards models and restricted cubic spline (RCS) analysis were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results Increased EC risk was associated with high HDL‐C levels (HRQ4vs.Q1 = 2.50, 95% CI: 1.57–3.98), while a U‐shaped relationship between HDL‐C and EC risk was revealed in the RCS analysis (poverall ≤ 0.0001, pnonlinear = 0.02). No robust association was identified between lipid biomarkers and GC risk. In multivariable analysis, increased CRC risk was positively associated with high TC levels (HRQ4vs.Q1 = 1.42, 95% CI: 1.11–1.83, ptrend = 0.03), dose–responsely negatively associated with LDL‐C levels over quartiles (HRQ2vs.Q1 = 0.83, 95% CI: 0.66–1.02; HRQ3vs.Q1 = 0.86, 95% CI: 0.69–1.07; HRQ4vs.Q1 = 0.68, 95% CI: 0.53–0.86, ptrend = 0.02), and showed a diminished negative association with HDL‐C levels over quartiles (HRQ2vs.Q1 = 0.75, 95% CI: 0.60–0.94; HRQ3vs.Q1 = 0.76, 95% CI: 0.61–0.95; HRQ4vs.Q1 = 0.91, 95% CI 0.74–1.13, ptrend = 0.02). The subsequent RCS analysis revealed a linear negative relationship of LDL‐C (poverall = 0.004, pnonlinear = 0.67) and a U‐shaped relationship of HDL‐C (poverall = 0.05, pnonlinear = 0.02) with CRC risk. Competitive risk analysis and sensitivity analysis confirmed the stability of our results. Conclusion We observed a U‐shaped relationship regarding HDL‐C levels with EC and CRC risk, and a linear inverse relationship between LDL‐C levels and CRC risk. Relevant serum lipid levels should be properly managed in high‐risk individuals of certain gastrointestinal cancers. |
| format | Article |
| id | doaj-art-159565002a5f4ae1a8338033be2c6ef3 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-02-01 |
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| series | Cancer Medicine |
| spelling | doaj-art-159565002a5f4ae1a8338033be2c6ef32025-08-20T03:27:10ZengWileyCancer Medicine2045-76342025-02-01143n/an/a10.1002/cam4.70654Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective StudyYing Xiao0Xin Du1Tianjie Wang2Dong Liu3Hongzhao You4Hao Wang5Hanyang Liang6Zhengqing Ba7Yilu Liu8Yu Ren9Jinghan Zeng10Weixian Yang11Shouling Wu12Jiansong Yuan13Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaDepartment of Cardiology Kailuan General Hospital Tangshan ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaPeking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaDepartment of Cardiology Kailuan General Hospital Tangshan ChinaFuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing ChinaABSTRACT Background Current evidence on relationships between serum lipid biomarkers and the risk of gastrointestinal cancers remains controversial, with no consensus reached. Methods We conducted a prospective cohort study within the Kailuan Cohort wherein 88,225 individuals with baseline information on triglyceride (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) was followed from 2006 to 2021 for the incidence of esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC). Cox proportional hazards models and restricted cubic spline (RCS) analysis were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results Increased EC risk was associated with high HDL‐C levels (HRQ4vs.Q1 = 2.50, 95% CI: 1.57–3.98), while a U‐shaped relationship between HDL‐C and EC risk was revealed in the RCS analysis (poverall ≤ 0.0001, pnonlinear = 0.02). No robust association was identified between lipid biomarkers and GC risk. In multivariable analysis, increased CRC risk was positively associated with high TC levels (HRQ4vs.Q1 = 1.42, 95% CI: 1.11–1.83, ptrend = 0.03), dose–responsely negatively associated with LDL‐C levels over quartiles (HRQ2vs.Q1 = 0.83, 95% CI: 0.66–1.02; HRQ3vs.Q1 = 0.86, 95% CI: 0.69–1.07; HRQ4vs.Q1 = 0.68, 95% CI: 0.53–0.86, ptrend = 0.02), and showed a diminished negative association with HDL‐C levels over quartiles (HRQ2vs.Q1 = 0.75, 95% CI: 0.60–0.94; HRQ3vs.Q1 = 0.76, 95% CI: 0.61–0.95; HRQ4vs.Q1 = 0.91, 95% CI 0.74–1.13, ptrend = 0.02). The subsequent RCS analysis revealed a linear negative relationship of LDL‐C (poverall = 0.004, pnonlinear = 0.67) and a U‐shaped relationship of HDL‐C (poverall = 0.05, pnonlinear = 0.02) with CRC risk. Competitive risk analysis and sensitivity analysis confirmed the stability of our results. Conclusion We observed a U‐shaped relationship regarding HDL‐C levels with EC and CRC risk, and a linear inverse relationship between LDL‐C levels and CRC risk. Relevant serum lipid levels should be properly managed in high‐risk individuals of certain gastrointestinal cancers.https://doi.org/10.1002/cam4.70654cancer risk factorscolorectal cancerdigestive cancergastric cancer |
| spellingShingle | Ying Xiao Xin Du Tianjie Wang Dong Liu Hongzhao You Hao Wang Hanyang Liang Zhengqing Ba Yilu Liu Yu Ren Jinghan Zeng Weixian Yang Shouling Wu Jiansong Yuan Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study Cancer Medicine cancer risk factors colorectal cancer digestive cancer gastric cancer |
| title | Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study |
| title_full | Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study |
| title_fullStr | Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study |
| title_full_unstemmed | Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study |
| title_short | Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study |
| title_sort | serum lipid biomarkers and the risk of gastrointestinal cancers in a chinese population the kailuan prospective study |
| topic | cancer risk factors colorectal cancer digestive cancer gastric cancer |
| url | https://doi.org/10.1002/cam4.70654 |
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