Cerebral hemodynamic and metabolic changes in fulminant hepatic failure

Cerebral hemodynamic and metabolic changes in fulminant hepatic failure

ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mec...

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Main Authors: Fernando Mendes Paschoal Junior, Ricardo de Carvalho Nogueira, Marcelo de Lima Oliveira, Eric Homero Albuquerque Paschoal, Manoel Jacobsen Teixeira, Luiz Augusto Carneiro D’Albuquerque, Edson Bor-Seng-Shu
Format: Article
Language:English
Published: Thieme Revinter Publicações
Series:Arquivos de Neuro-Psiquiatria
Subjects:
hepatic insufficiency
intracranial hypertension
brain edema
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000700470&lng=en&tlng=en
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Summary:ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.
ISSN:1678-4227

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