Carboxymethyl-lysine is a Prominent Target of Circulating IgA in IgA Nephropathy

Carboxymethyl-lysine is a Prominent Target of Circulating IgA in IgA Nephropathy

Introduction: IgA nephropathy (IgAN), the most prevalent glomerular disease worldwide, carries a significant risk of kidney failure. Its pathogenesis involves the presence of elevated levels of IgA and galactose-deficient IgA (Gd-IgA), deposition of these antibodies in the kidney mesangium, and comp...

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Main Authors: Sara Alibrandi, Talita Aguiar, Mattea Ausmeier, Paolo Molinari, Enrico Fiaccadori, Umberto Maggiore, Nicholas Chun, Maria Lanau, Mario Perez-Arnedo, Joaquin Manrique, Paolo Cravedi, Emmanuel Zorn
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Kidney International Reports
Subjects:
biomarker
biopsy
chemical adduct
IgA nephropathy
kidney disease
proteinuria
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024925002335
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