Skin in the game: a review of computational models of the skin
Abstract With the vast advances in computing technology, computational (or in silico) modelling has emerged as a transformative tool in dermatology. These findings can provide novel insights into complex biological processes and aid in the development of innovative therapeutic and regenerative strat...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | BioData Mining |
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| Online Access: | https://doi.org/10.1186/s13040-025-00471-8 |
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| author | Seda Ceylan Didem Demir Cayla Harris Semih Latif İpek Vasileios Vavourakis Marco Manca Sandrine Dubrac Roman Bauer |
| author_facet | Seda Ceylan Didem Demir Cayla Harris Semih Latif İpek Vasileios Vavourakis Marco Manca Sandrine Dubrac Roman Bauer |
| author_sort | Seda Ceylan |
| collection | DOAJ |
| description | Abstract With the vast advances in computing technology, computational (or in silico) modelling has emerged as a transformative tool in dermatology. These findings can provide novel insights into complex biological processes and aid in the development of innovative therapeutic and regenerative strategies for the skin. Modelling combines experimental data and knowledge across multiple disciplines, serving as a common framework to elucidate the workings of the skin. From a biomedical perspective, the mechanisms of skin diseases can be studied by simulating cellular interactions and signalling pathways. Computational investigations of these mechanisms can be categorised into two distinct approaches: data-driven and model-based. Data-driven approaches allow the diagnosis of skin diseases on the basis of data collection via imaging or feedback from portable sensors, often yielding performance exceeding that of their human counterparts. Model-based methods are well suited to address topics such as skin cell biology and biomechanics, contributing to wound healing and skin cancer research. Furthermore, such modelling has found utility in the development of virtual skin models and skin-on-chip devices, enabling the prediction of skin responses to various substances, including cosmetics and drugs. In the realm of dermatological surgery, computational tools have been instrumental in optimizing surgical planning and improving clinical outcomes. While significant advancements have been made, challenges such as data availability, model validation, and interdisciplinary collaboration persist. This review highlights the current state-of-the-art in computational modeling in dermatology, identifies key challenges, and outlines its prospects. |
| format | Article |
| id | doaj-art-158dc734f6e0428cac86efd4bbb5c171 |
| institution | Kabale University |
| issn | 1756-0381 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BioData Mining |
| spelling | doaj-art-158dc734f6e0428cac86efd4bbb5c1712025-08-24T11:11:20ZengBMCBioData Mining1756-03812025-08-0118112610.1186/s13040-025-00471-8Skin in the game: a review of computational models of the skinSeda Ceylan0Didem Demir1Cayla Harris2Semih Latif İpek3Vasileios Vavourakis4Marco Manca5Sandrine Dubrac6Roman Bauer7Department of Bioengineering, Adana Alparslan Türkeş Science and Technology UniversityDepartment of Chemistry and Chemical Process Technologies, Tarsus UniversityNICE research group, School of Computer Science and Electronic Engineering, University of SurreyDepartment of Food Engineering, Adana Alparslan Türkeş Science and Technology UniversityDepartment of Medical Physics and Biomedical Engineering, University College LondonSCimPulse FoundationDepartment of Dermatology, Venereology and Allergology, Medical University of InnsbruckNICE research group, School of Computer Science and Electronic Engineering, University of SurreyAbstract With the vast advances in computing technology, computational (or in silico) modelling has emerged as a transformative tool in dermatology. These findings can provide novel insights into complex biological processes and aid in the development of innovative therapeutic and regenerative strategies for the skin. Modelling combines experimental data and knowledge across multiple disciplines, serving as a common framework to elucidate the workings of the skin. From a biomedical perspective, the mechanisms of skin diseases can be studied by simulating cellular interactions and signalling pathways. Computational investigations of these mechanisms can be categorised into two distinct approaches: data-driven and model-based. Data-driven approaches allow the diagnosis of skin diseases on the basis of data collection via imaging or feedback from portable sensors, often yielding performance exceeding that of their human counterparts. Model-based methods are well suited to address topics such as skin cell biology and biomechanics, contributing to wound healing and skin cancer research. Furthermore, such modelling has found utility in the development of virtual skin models and skin-on-chip devices, enabling the prediction of skin responses to various substances, including cosmetics and drugs. In the realm of dermatological surgery, computational tools have been instrumental in optimizing surgical planning and improving clinical outcomes. While significant advancements have been made, challenges such as data availability, model validation, and interdisciplinary collaboration persist. This review highlights the current state-of-the-art in computational modeling in dermatology, identifies key challenges, and outlines its prospects.https://doi.org/10.1186/s13040-025-00471-8SkinDermisEpidermisModellingSkin biomechanicsComputational dermatology |
| spellingShingle | Seda Ceylan Didem Demir Cayla Harris Semih Latif İpek Vasileios Vavourakis Marco Manca Sandrine Dubrac Roman Bauer Skin in the game: a review of computational models of the skin BioData Mining Skin Dermis Epidermis Modelling Skin biomechanics Computational dermatology |
| title | Skin in the game: a review of computational models of the skin |
| title_full | Skin in the game: a review of computational models of the skin |
| title_fullStr | Skin in the game: a review of computational models of the skin |
| title_full_unstemmed | Skin in the game: a review of computational models of the skin |
| title_short | Skin in the game: a review of computational models of the skin |
| title_sort | skin in the game a review of computational models of the skin |
| topic | Skin Dermis Epidermis Modelling Skin biomechanics Computational dermatology |
| url | https://doi.org/10.1186/s13040-025-00471-8 |
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