Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome
Purpose This study examined whether Cystochon® (cranberry extract, chondroitin sulfate, and hyaluronic acid complex) effectively improves the symptoms and problems of interstitial cystitis/bladder pain syndrome (IC/BPS) patients. Materials and Methods From December 2021 to May 2022, the medical reco...
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Korean Association of Urogenital Tract Infection and Inflammation
2022-08-01
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| Series: | Urogenital Tract Infection |
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| Online Access: | http://euti.org/upload/pdf/uti-17-2-36.pdf |
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| author | Kwang Taek Kim Jeong Woo Lee Hyun-Sop Choe |
| author_facet | Kwang Taek Kim Jeong Woo Lee Hyun-Sop Choe |
| author_sort | Kwang Taek Kim |
| collection | DOAJ |
| description | Purpose This study examined whether Cystochon® (cranberry extract, chondroitin sulfate, and hyaluronic acid complex) effectively improves the symptoms and problems of interstitial cystitis/bladder pain syndrome (IC/BPS) patients. Materials and Methods From December 2021 to May 2022, the medical records of IC/BPS patients who visited St. Vincent’s Hospital, Kyung Hee University Medical Center, or Gachon University Gil Medical Center were collected. For the treatment of IC/BPS, the patients were given pentosan polysulfate (PPS) for 12 weeks, with Cystochon® then added and maintained for an additional eight weeks. The OʼLeary–Sant symptom and problem index (Interstitial Cystitis Symptom Index [ICSI], Interstitial Cystitis Problem Index [ICPI]) was used to measure the treatment response. Results After 12 weeks of PPS treatment, ICSI and ICPI improved in all patients. After adding Cystochon® for eight weeks, the ICSI and ICPI indicators improved further. In the ICSI category, significant improvement in symptoms was confirmed in the total ICSI score, particularly in the Q4 (pain-related) questionnaire after adding Cystochon®. In the ICPI category, significant problem improvement was confirmed in the total ICPI score, particularly in the Q1 (frequent urination) and Q4 (pain-related) questionnaires. Although not statistically significant, the remaining indicators generally tended to improve. Conclusions The orally administered combination of cranberry extract, chondroitin sulfate, and hyaluronic acid (Cystochon®) may have a clinically positive effect in patients with IC/BPS. Better clinical improvement can be expected when it is added to the PPS treatment, especially in the category of bladder pain. |
| format | Article |
| id | doaj-art-158db5d7f1df408ba37b3e156b8f55af |
| institution | Kabale University |
| issn | 2465-8243 2465-8510 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Korean Association of Urogenital Tract Infection and Inflammation |
| record_format | Article |
| series | Urogenital Tract Infection |
| spelling | doaj-art-158db5d7f1df408ba37b3e156b8f55af2025-08-20T03:32:08ZengKorean Association of Urogenital Tract Infection and InflammationUrogenital Tract Infection2465-82432465-85102022-08-01172364110.14777/uti.2022.17.2.36381Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain SyndromeKwang Taek Kim0Jeong Woo Lee1Hyun-Sop Choe2Department of Urology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, KoreaDepartment of Urology, Kyung Hee University Medical Center, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Urology, St. Vincentʼs Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaPurpose This study examined whether Cystochon® (cranberry extract, chondroitin sulfate, and hyaluronic acid complex) effectively improves the symptoms and problems of interstitial cystitis/bladder pain syndrome (IC/BPS) patients. Materials and Methods From December 2021 to May 2022, the medical records of IC/BPS patients who visited St. Vincent’s Hospital, Kyung Hee University Medical Center, or Gachon University Gil Medical Center were collected. For the treatment of IC/BPS, the patients were given pentosan polysulfate (PPS) for 12 weeks, with Cystochon® then added and maintained for an additional eight weeks. The OʼLeary–Sant symptom and problem index (Interstitial Cystitis Symptom Index [ICSI], Interstitial Cystitis Problem Index [ICPI]) was used to measure the treatment response. Results After 12 weeks of PPS treatment, ICSI and ICPI improved in all patients. After adding Cystochon® for eight weeks, the ICSI and ICPI indicators improved further. In the ICSI category, significant improvement in symptoms was confirmed in the total ICSI score, particularly in the Q4 (pain-related) questionnaire after adding Cystochon®. In the ICPI category, significant problem improvement was confirmed in the total ICPI score, particularly in the Q1 (frequent urination) and Q4 (pain-related) questionnaires. Although not statistically significant, the remaining indicators generally tended to improve. Conclusions The orally administered combination of cranberry extract, chondroitin sulfate, and hyaluronic acid (Cystochon®) may have a clinically positive effect in patients with IC/BPS. Better clinical improvement can be expected when it is added to the PPS treatment, especially in the category of bladder pain.http://euti.org/upload/pdf/uti-17-2-36.pdfinterstitial cystitisbladder pain syndromecranberrychondroitin sulfateshyaluronic acid |
| spellingShingle | Kwang Taek Kim Jeong Woo Lee Hyun-Sop Choe Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome Urogenital Tract Infection interstitial cystitis bladder pain syndrome cranberry chondroitin sulfates hyaluronic acid |
| title | Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome |
| title_full | Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome |
| title_fullStr | Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome |
| title_full_unstemmed | Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome |
| title_short | Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome |
| title_sort | pilot study of cystochon r cranberry extract chondroitin sulfate and hyaluronic acid complex in interstitial cystitis bladder pain syndrome |
| topic | interstitial cystitis bladder pain syndrome cranberry chondroitin sulfates hyaluronic acid |
| url | http://euti.org/upload/pdf/uti-17-2-36.pdf |
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