Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis
Aim. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and MCNS susceptibility. Method. A predefined literature search and selection of eligible relevant studies were performed to collect the data from electronic databases. Results. Six articles were id...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/360357 |
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| author | Tian-Biao Zhou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao |
| author_facet | Tian-Biao Zhou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao |
| author_sort | Tian-Biao Zhou |
| collection | DOAJ |
| description | Aim. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and MCNS susceptibility.
Method. A predefined literature search and selection of eligible relevant studies were performed to collect the data from electronic databases.
Results. Six articles were identified for the analysis of association between ACE I/D gene polymorphism and MCNS risk, including 4 for Asians, one in Caucasian population and one for Africans. There was a markedly positive association between D allele or DD genotype and MCNS susceptibility in Asians (D: 𝑃=.01, DD: 𝑃=.02), but not for Caucasians and Africans (Caucasians: D: 𝑃=.16, DD: 𝑃=.98;
Africans: D: 𝑃=.81, DD: 𝑃=.49). Furthermore, the II genotype seemed not to play a protective role against MCNS risk for Asians, Caucasians and Africans (𝑃=.12, 𝑃=.09, 𝑃=.76, resp.). Interestingly, there was also significant association between ACE I/D gene polymorphism and MCNS susceptibility in overall populations (D: 𝑃=.007, DD: 𝑃=.04, II: 𝑃=.03).
Conclusion. D allele or DD genotype might be a significant genetic molecular marker for MCNS susceptibility in Asians and overall populations, but not for Caucasians and Africans. More larger and rigorous genetic epidemiological investigations are required to further explore this association. |
| format | Article |
| id | doaj-art-15892ba4851747e893dc6e2a3301d35f |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-15892ba4851747e893dc6e2a3301d35f2025-08-20T03:54:25ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/360357360357Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-AnalysisTian-Biao Zhou0Yuan-Han Qin1Li-Na Su2Feng-Ying Lei3Wei-Fang Huang4Yan-Jun Zhao5Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaAim. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and MCNS susceptibility. Method. A predefined literature search and selection of eligible relevant studies were performed to collect the data from electronic databases. Results. Six articles were identified for the analysis of association between ACE I/D gene polymorphism and MCNS risk, including 4 for Asians, one in Caucasian population and one for Africans. There was a markedly positive association between D allele or DD genotype and MCNS susceptibility in Asians (D: 𝑃=.01, DD: 𝑃=.02), but not for Caucasians and Africans (Caucasians: D: 𝑃=.16, DD: 𝑃=.98; Africans: D: 𝑃=.81, DD: 𝑃=.49). Furthermore, the II genotype seemed not to play a protective role against MCNS risk for Asians, Caucasians and Africans (𝑃=.12, 𝑃=.09, 𝑃=.76, resp.). Interestingly, there was also significant association between ACE I/D gene polymorphism and MCNS susceptibility in overall populations (D: 𝑃=.007, DD: 𝑃=.04, II: 𝑃=.03). Conclusion. D allele or DD genotype might be a significant genetic molecular marker for MCNS susceptibility in Asians and overall populations, but not for Caucasians and Africans. More larger and rigorous genetic epidemiological investigations are required to further explore this association.http://dx.doi.org/10.4061/2011/360357 |
| spellingShingle | Tian-Biao Zhou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis International Journal of Nephrology |
| title | Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis |
| title_full | Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis |
| title_fullStr | Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis |
| title_full_unstemmed | Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis |
| title_short | Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and Susceptibility of Minimal Change Nephrotic Syndrome: A Meta-Analysis |
| title_sort | relationship between angiotensin converting enzyme insertion deletion gene polymorphism and susceptibility of minimal change nephrotic syndrome a meta analysis |
| url | http://dx.doi.org/10.4061/2011/360357 |
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