Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity
6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with h...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/873470 |
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| author | Kartick Chandra Samanta Mohd. Asif Pooja Vikas Garg Priyanka Sharma Ravinder Singh |
| author_facet | Kartick Chandra Samanta Mohd. Asif Pooja Vikas Garg Priyanka Sharma Ravinder Singh |
| author_sort | Kartick Chandra Samanta |
| collection | DOAJ |
| description | 6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity. |
| format | Article |
| id | doaj-art-1588f3998739480f92e1acdf71d99457 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-1588f3998739480f92e1acdf71d994572025-02-03T05:57:08ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018124525110.1155/2011/873470Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant ActivityKartick Chandra Samanta0Mohd. Asif1Pooja2Vikas Garg3Priyanka Sharma4Ravinder Singh5School of Pharmacy, Suresh Gyan Vihar University, Jaipur-302025, IndiaDepartment of Pharmacy, GRD (PG) Institute of Management & Technology214, Rajpur Road, Dehradun, Uttarakhand, IndiaSchool of Pharmacy, Suresh Gyan Vihar University, Jaipur-302025, IndiaManipal College of Pharmaceutical Sciences, Manipal-576104, IndiaSchool of Pharmacy, Suresh Gyan Vihar University, Jaipur-302025, IndiaNandha College of Pharmacy and Research Institute, Erode, Tamilnadu, India6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.http://dx.doi.org/10.1155/2011/873470 |
| spellingShingle | Kartick Chandra Samanta Mohd. Asif Pooja Vikas Garg Priyanka Sharma Ravinder Singh Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity E-Journal of Chemistry |
| title | Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity |
| title_full | Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity |
| title_fullStr | Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity |
| title_full_unstemmed | Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity |
| title_short | Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity |
| title_sort | synthesis of different substituted pyridazinone derivatives and their anticonvulsant activity |
| url | http://dx.doi.org/10.1155/2011/873470 |
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