Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population

Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population

Abstract Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Brazilian patients with COVID-19 to investi...

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Main Authors: Gustavo Medina Tavares, Bruna Oliveira Missaggia, Nathan Araujo Cadore, Renan César Sbruzzi, Marilea Furtado Feira, Giovanna Câmara Giudicelli, Bibiana Sampaio de Oliveira Fam, Maira Rodrigues, Márcio Dorn, Tábita Hünemeier, Fernanda Sales Luiz Vianna, Maria Cátira Bortolini
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
COVID-19
mtDNA
Haplogroup A2
Native American
Mitochondria
Pandemics
Online Access:https://doi.org/10.1038/s41598-025-03578-4
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