Targeting PRDX1 impairs acute myeloid leukemic blasts and stem cells by disrupting redox homeostasis

Targeting PRDX1 impairs acute myeloid leukemic blasts and stem cells by disrupting redox homeostasis

Abstract Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with a poor prognosis and limited therapeutic options. Leukemic stem cells (LSCs), which drive disease progression and confer resistance to therapy, pose a significant challenge to conventional treatment strategies. In thi...

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Bibliographic Details
Main Authors: Zhenghao Li, Guangci Liu, Ziren Chen, Keming Li, Zhe Yu, Chao He, Xinyu Ying, Danling Huang, Chengtian Tao, Sajid Khan, Yimeng Wang, Fang-Lin Zhang, Huan Li, Yun Chen, Jingfeng Zhou, Li Yu, Thomas J. Kipps, Yongxian Cheng, Suping Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07831-6
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