Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis
BackgroundCardiovascular disease remains the leading cause of mortality and disability worldwide. Hypercholesterolemia is a significant causal factor of ischemic heart disease, contributing to half of all cardiovascular fatalities.MethodsThis study utilized bibliometric tools to offer a comprehensiv...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1524697/full |
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| author | Haoxin Guo Haoxin Guo Qihui Wang Qihui Wang Yinling Wang Yinling Wang Xiaolong Dong Xiaolong Dong Zhongqing Wang Hui Kang Hui Kang Shitong Cheng Shitong Cheng |
| author_facet | Haoxin Guo Haoxin Guo Qihui Wang Qihui Wang Yinling Wang Yinling Wang Xiaolong Dong Xiaolong Dong Zhongqing Wang Hui Kang Hui Kang Shitong Cheng Shitong Cheng |
| author_sort | Haoxin Guo |
| collection | DOAJ |
| description | BackgroundCardiovascular disease remains the leading cause of mortality and disability worldwide. Hypercholesterolemia is a significant causal factor of ischemic heart disease, contributing to half of all cardiovascular fatalities.MethodsThis study utilized bibliometric tools to offer a comprehensive overview of the current research trends in hypercholesterolemia. The full records and cited references from 18,641 publications (2003–2023) were retrieved from the Web of Science Core Collection, and bibliometric analysis was conducted using VOSviewer.ResultsThe United States and Harvard University had the most significant influence among the countries/regions and research institutions, respectively. Among the researchers, Kastelein J.J.P. published the highest number of related articles, whereas publications by Sabatine M.S. had the highest average citation. The top 10 keywords were atherosclerosis, familial hypercholesterolemia, cardiovascular disease, risk, risk factors, gene expression, coronary heart disease, low-density lipoprotein, statins, and prevalence. These high-frequency keywords were clustered into groups based on the pathogenic mechanisms, disease prevalence and prevention, drugs and treatments, and familial hypercholesterolemia. These clusters denote distinct study fields and current research hotspots for hypercholesterolemia.ConclusionThrough bibliometric and visual analysis, this study comprehensively assessed global research trends and focal areas within hypercholesterolemia, offering valuable insights into current and future research directions in the field. Further research is needed on the relationship between the intestinal microbiota and cholesterol metabolism and on the advancement of microbiota therapy and precision medicine. |
| format | Article |
| id | doaj-art-157f0575fe5a4bb5ba93b034b5eb4f9f |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-157f0575fe5a4bb5ba93b034b5eb4f9f2025-08-20T02:09:24ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.15246971524697Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysisHaoxin Guo0Haoxin Guo1Qihui Wang2Qihui Wang3Yinling Wang4Yinling Wang5Xiaolong Dong6Xiaolong Dong7Zhongqing Wang8Hui Kang9Hui Kang10Shitong Cheng11Shitong Cheng12Department of Information Center, The First Hospital of China Medical University, Shenyang, ChinaSchool of Health Management, China Medical University, Shenyang, ChinaNational Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaLaboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaLaboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaLaboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences, Shenyang, ChinaDepartment of Information Center, The First Hospital of China Medical University, Shenyang, ChinaNational Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaLaboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaLaboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences, Shenyang, ChinaBackgroundCardiovascular disease remains the leading cause of mortality and disability worldwide. Hypercholesterolemia is a significant causal factor of ischemic heart disease, contributing to half of all cardiovascular fatalities.MethodsThis study utilized bibliometric tools to offer a comprehensive overview of the current research trends in hypercholesterolemia. The full records and cited references from 18,641 publications (2003–2023) were retrieved from the Web of Science Core Collection, and bibliometric analysis was conducted using VOSviewer.ResultsThe United States and Harvard University had the most significant influence among the countries/regions and research institutions, respectively. Among the researchers, Kastelein J.J.P. published the highest number of related articles, whereas publications by Sabatine M.S. had the highest average citation. The top 10 keywords were atherosclerosis, familial hypercholesterolemia, cardiovascular disease, risk, risk factors, gene expression, coronary heart disease, low-density lipoprotein, statins, and prevalence. These high-frequency keywords were clustered into groups based on the pathogenic mechanisms, disease prevalence and prevention, drugs and treatments, and familial hypercholesterolemia. These clusters denote distinct study fields and current research hotspots for hypercholesterolemia.ConclusionThrough bibliometric and visual analysis, this study comprehensively assessed global research trends and focal areas within hypercholesterolemia, offering valuable insights into current and future research directions in the field. Further research is needed on the relationship between the intestinal microbiota and cholesterol metabolism and on the advancement of microbiota therapy and precision medicine.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1524697/fullhypercholesterolemiafamilial hypercholesterolemiacardiovascular diseasebibliometric analysisVOSviewer |
| spellingShingle | Haoxin Guo Haoxin Guo Qihui Wang Qihui Wang Yinling Wang Yinling Wang Xiaolong Dong Xiaolong Dong Zhongqing Wang Hui Kang Hui Kang Shitong Cheng Shitong Cheng Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis Frontiers in Cardiovascular Medicine hypercholesterolemia familial hypercholesterolemia cardiovascular disease bibliometric analysis VOSviewer |
| title | Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis |
| title_full | Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis |
| title_fullStr | Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis |
| title_full_unstemmed | Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis |
| title_short | Global scientific trends in hypercholesterolemia research from 2003 to 2023: a data-driven bibliometric and visual analysis |
| title_sort | global scientific trends in hypercholesterolemia research from 2003 to 2023 a data driven bibliometric and visual analysis |
| topic | hypercholesterolemia familial hypercholesterolemia cardiovascular disease bibliometric analysis VOSviewer |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1524697/full |
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