Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report
Objective To analyze the clinical outcomes of a patient with thrombotic thrombocytopenic purpura(TTP) as the starting performance who was considered as systemic lupus erythematosus(SLE) under multiple abnormal autoantibodies, and summarize the treatment experience through the clinical outcomes of pl...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2024-10-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.10.018&lang=en |
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| author | LI Xu LIU Fangjiu YANG Hong |
| author_facet | LI Xu LIU Fangjiu YANG Hong |
| author_sort | LI Xu |
| collection | DOAJ |
| description | Objective To analyze the clinical outcomes of a patient with thrombotic thrombocytopenic purpura(TTP) as the starting performance who was considered as systemic lupus erythematosus(SLE) under multiple abnormal autoantibodies, and summarize the treatment experience through the clinical outcomes of plasma exchange combined with high-does steroid pulse therapy. Methods A middle-aged female patient presented with initial symptoms of fever, bleeding and hemolytic thrombocytopenia. Laboratory tests showed decreased activity of thrombospondin type 1 motif no.13(ADAMT13) and abnormal autoantibodies. The diagnosis was considered SLE with TTP, and the patient underwent continuous plasma exchange combined with high-dose steroid pulse therapy. The patient's platelet recovery was dynamically observed. Results The patient responded well to plasma exchange combined with high-does steroid pulse therapy, with platelet count raising to normal in a short period of time and hormone gradually decreasing. There was no recurrence during the follow-up period. Conclusion TTP combined with lupus is not common, but when both occur simultaneously, plasma exchange combined with high-does steroid pulse therapy may effectively alleviate symptoms. This treatment approach can serve as a valuable reference for similar clinical cases. |
| format | Article |
| id | doaj-art-1577ed7dbc8f432f99b0fe7380e6c10b |
| institution | OA Journals |
| issn | 1004-549X |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-1577ed7dbc8f432f99b0fe7380e6c10b2025-08-20T02:12:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2024-10-0137101189119210.13303/j.cjbt.issn.1004-549x.2024.10.0181004-549X(2024)10-1189-04Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case reportLI Xu0LIU Fangjiu1YANG Hong2Suining Central Hospital, Suining 629000, ChinaSuining Central Hospital, Suining 629000, ChinaSuining Central Hospital, Suining 629000, ChinaObjective To analyze the clinical outcomes of a patient with thrombotic thrombocytopenic purpura(TTP) as the starting performance who was considered as systemic lupus erythematosus(SLE) under multiple abnormal autoantibodies, and summarize the treatment experience through the clinical outcomes of plasma exchange combined with high-does steroid pulse therapy. Methods A middle-aged female patient presented with initial symptoms of fever, bleeding and hemolytic thrombocytopenia. Laboratory tests showed decreased activity of thrombospondin type 1 motif no.13(ADAMT13) and abnormal autoantibodies. The diagnosis was considered SLE with TTP, and the patient underwent continuous plasma exchange combined with high-dose steroid pulse therapy. The patient's platelet recovery was dynamically observed. Results The patient responded well to plasma exchange combined with high-does steroid pulse therapy, with platelet count raising to normal in a short period of time and hormone gradually decreasing. There was no recurrence during the follow-up period. Conclusion TTP combined with lupus is not common, but when both occur simultaneously, plasma exchange combined with high-does steroid pulse therapy may effectively alleviate symptoms. This treatment approach can serve as a valuable reference for similar clinical cases.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.10.018&lang=enplasma exchangehigh-dose steroid pulsesystemic lupus erythematosus(sle)thrombotic thrombocytopenic purpura(ttp) |
| spellingShingle | LI Xu LIU Fangjiu YANG Hong Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report Zhongguo shuxue zazhi plasma exchange high-dose steroid pulse systemic lupus erythematosus(sle) thrombotic thrombocytopenic purpura(ttp) |
| title | Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report |
| title_full | Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report |
| title_fullStr | Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report |
| title_full_unstemmed | Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report |
| title_short | Systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high-dose steroid pulse therapy: a case report |
| title_sort | systemic lupus erythematosus induced thrombotic thrombocytopenic purpura treated with plasma exchange combined with high dose steroid pulse therapy a case report |
| topic | plasma exchange high-dose steroid pulse systemic lupus erythematosus(sle) thrombotic thrombocytopenic purpura(ttp) |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.10.018&lang=en |
| work_keys_str_mv | AT lixu systemiclupuserythematosusinducedthromboticthrombocytopenicpurpuratreatedwithplasmaexchangecombinedwithhighdosesteroidpulsetherapyacasereport AT liufangjiu systemiclupuserythematosusinducedthromboticthrombocytopenicpurpuratreatedwithplasmaexchangecombinedwithhighdosesteroidpulsetherapyacasereport AT yanghong systemiclupuserythematosusinducedthromboticthrombocytopenicpurpuratreatedwithplasmaexchangecombinedwithhighdosesteroidpulsetherapyacasereport |