Immunomodulation by allograft endothelial cells
It is increasingly appreciated that the expression of immunoregulatory molecules within tumors have potential to shape a microenvironment that promotes local immunoevasion and immunoregulation. However, little is known about tissue-intrinsic immunomodulatory mechanisms following transplantation. We...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2025.1518772/full |
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| author | Sayantan Bose Sayantan Bose Sayantan Bose Sayantan Bose Vicki Do Vicki Do Chiara Testini Chiara Testini Chiara Testini Chiara Testini Suchita S. Jadhav Suchita S. Jadhav Suchita S. Jadhav Suchita S. Jadhav Nicolas Sailliet Nicolas Sailliet Nicolas Sailliet Nicolas Sailliet Alvin T. Kho Alvin T. Kho Alvin T. Kho Alvin T. Kho Masaki Komatsu Masaki Komatsu Masaki Komatsu Masaki Komatsu Leo Boneschansker Leo Boneschansker Leo Boneschansker Leo Boneschansker Sek Won Kong Sek Won Kong Sek Won Kong Sek Won Kong Johannes Wedel Johannes Wedel Johannes Wedel Johannes Wedel Johannes Wedel David M. Briscoe David M. Briscoe David M. Briscoe David M. Briscoe |
| author_facet | Sayantan Bose Sayantan Bose Sayantan Bose Sayantan Bose Vicki Do Vicki Do Chiara Testini Chiara Testini Chiara Testini Chiara Testini Suchita S. Jadhav Suchita S. Jadhav Suchita S. Jadhav Suchita S. Jadhav Nicolas Sailliet Nicolas Sailliet Nicolas Sailliet Nicolas Sailliet Alvin T. Kho Alvin T. Kho Alvin T. Kho Alvin T. Kho Masaki Komatsu Masaki Komatsu Masaki Komatsu Masaki Komatsu Leo Boneschansker Leo Boneschansker Leo Boneschansker Leo Boneschansker Sek Won Kong Sek Won Kong Sek Won Kong Sek Won Kong Johannes Wedel Johannes Wedel Johannes Wedel Johannes Wedel Johannes Wedel David M. Briscoe David M. Briscoe David M. Briscoe David M. Briscoe |
| author_sort | Sayantan Bose |
| collection | DOAJ |
| description | It is increasingly appreciated that the expression of immunoregulatory molecules within tumors have potential to shape a microenvironment that promotes local immunoevasion and immunoregulation. However, little is known about tissue-intrinsic immunomodulatory mechanisms following transplantation. We propose that differences in the phenotype of microvascular endothelial cells impact the alloantigenicity of the graft and its potential to promote immunoregulation following transplantation. We focus this review on the concept that graft-dependent immunoregulation may evolve post-transplantation, and that it is dependent on the phenotype of select subsets of intragraft endothelial cells. We also discuss evidence that long-term graft survival is critically dependent on adaptive interactions among immune cells and endothelial cells within the transplanted tissue microenvironment. |
| format | Article |
| id | doaj-art-15776a7afde9470893a78f7ee2d03459 |
| institution | Kabale University |
| issn | 2813-2440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj-art-15776a7afde9470893a78f7ee2d034592025-02-04T06:31:57ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402025-02-01410.3389/frtra.2025.15187721518772Immunomodulation by allograft endothelial cellsSayantan Bose0Sayantan Bose1Sayantan Bose2Sayantan Bose3Vicki Do4Vicki Do5Chiara Testini6Chiara Testini7Chiara Testini8Chiara Testini9Suchita S. Jadhav10Suchita S. Jadhav11Suchita S. Jadhav12Suchita S. Jadhav13Nicolas Sailliet14Nicolas Sailliet15Nicolas Sailliet16Nicolas Sailliet17Alvin T. Kho18Alvin T. Kho19Alvin T. Kho20Alvin T. Kho21Masaki Komatsu22Masaki Komatsu23Masaki Komatsu24Masaki Komatsu25Leo Boneschansker26Leo Boneschansker27Leo Boneschansker28Leo Boneschansker29Sek Won Kong30Sek Won Kong31Sek Won Kong32Sek Won Kong33Johannes Wedel34Johannes Wedel35Johannes Wedel36Johannes Wedel37Johannes Wedel38David M. Briscoe39David M. Briscoe40David M. Briscoe41David M. Briscoe42Transplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesComputational Health Informatics Program, Boston Children’s Hospital, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesComputational Health Informatics Program, Boston Children’s Hospital, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesComputational Health Informatics Program, Boston Children’s Hospital, Boston, MA, United StatesTransplant Research Program, Boston Children’s Hospital, Boston, MA, United StatesDivision of Nephrology, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Boston Children’s Hospital, Boston, MA, United StatesThe Department of Pediatrics, Harvard Medical School, Boston, MA, United StatesIt is increasingly appreciated that the expression of immunoregulatory molecules within tumors have potential to shape a microenvironment that promotes local immunoevasion and immunoregulation. However, little is known about tissue-intrinsic immunomodulatory mechanisms following transplantation. We propose that differences in the phenotype of microvascular endothelial cells impact the alloantigenicity of the graft and its potential to promote immunoregulation following transplantation. We focus this review on the concept that graft-dependent immunoregulation may evolve post-transplantation, and that it is dependent on the phenotype of select subsets of intragraft endothelial cells. We also discuss evidence that long-term graft survival is critically dependent on adaptive interactions among immune cells and endothelial cells within the transplanted tissue microenvironment.https://www.frontiersin.org/articles/10.3389/frtra.2025.1518772/fullendothelial cellallograft (ALLO)immunoregulationtransplantationgraft survival |
| spellingShingle | Sayantan Bose Sayantan Bose Sayantan Bose Sayantan Bose Vicki Do Vicki Do Chiara Testini Chiara Testini Chiara Testini Chiara Testini Suchita S. Jadhav Suchita S. Jadhav Suchita S. Jadhav Suchita S. Jadhav Nicolas Sailliet Nicolas Sailliet Nicolas Sailliet Nicolas Sailliet Alvin T. Kho Alvin T. Kho Alvin T. Kho Alvin T. Kho Masaki Komatsu Masaki Komatsu Masaki Komatsu Masaki Komatsu Leo Boneschansker Leo Boneschansker Leo Boneschansker Leo Boneschansker Sek Won Kong Sek Won Kong Sek Won Kong Sek Won Kong Johannes Wedel Johannes Wedel Johannes Wedel Johannes Wedel Johannes Wedel David M. Briscoe David M. Briscoe David M. Briscoe David M. Briscoe Immunomodulation by allograft endothelial cells Frontiers in Transplantation endothelial cell allograft (ALLO) immunoregulation transplantation graft survival |
| title | Immunomodulation by allograft endothelial cells |
| title_full | Immunomodulation by allograft endothelial cells |
| title_fullStr | Immunomodulation by allograft endothelial cells |
| title_full_unstemmed | Immunomodulation by allograft endothelial cells |
| title_short | Immunomodulation by allograft endothelial cells |
| title_sort | immunomodulation by allograft endothelial cells |
| topic | endothelial cell allograft (ALLO) immunoregulation transplantation graft survival |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2025.1518772/full |
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