Patient-derived xenograft model: Applications and challenges in liver cancer
Abstract. Liver cancer is one of the most common malignant tumors worldwide. Currently, the available treatment methods cannot fully control its recurrence and mortality rate. Establishing appropriate animal models for liver cancer is crucial for developing new treatment technologies and strategies....
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-06-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003480 |
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| _version_ | 1850162017914060800 |
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| author | Shuangshuang Dou Yunfei Huo Minghui Gao Quanwei Li Buxin Kou Mengyin Chai Xiaoni Liu Yanjie Yin |
| author_facet | Shuangshuang Dou Yunfei Huo Minghui Gao Quanwei Li Buxin Kou Mengyin Chai Xiaoni Liu Yanjie Yin |
| author_sort | Shuangshuang Dou |
| collection | DOAJ |
| description | Abstract. Liver cancer is one of the most common malignant tumors worldwide. Currently, the available treatment methods cannot fully control its recurrence and mortality rate. Establishing appropriate animal models for liver cancer is crucial for developing new treatment technologies and strategies. The patient-derived xenograft (PDX) model preserves the tumor’s microenvironment and heterogeneity, which makes it advantageous for biological research, drug evaluation, personalized medicine, and other purposes. This article reviews the development, preparation techniques, application fields, and challenges of PDX models in liver cancer, providing insights for the research and exploration of PDX models in diagnostic and therapeutic strategies of liver cancer. |
| format | Article |
| id | doaj-art-1576d971e2ee44e8bdd45295716ce9e6 |
| institution | OA Journals |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-1576d971e2ee44e8bdd45295716ce9e62025-08-20T02:22:40ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-06-01138111313132310.1097/CM9.0000000000003480202506050-00005Patient-derived xenograft model: Applications and challenges in liver cancerShuangshuang Dou0Yunfei Huo1Minghui Gao2Quanwei Li3Buxin Kou4Mengyin Chai5Xiaoni Liu6Yanjie YinBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, ChinaAbstract. Liver cancer is one of the most common malignant tumors worldwide. Currently, the available treatment methods cannot fully control its recurrence and mortality rate. Establishing appropriate animal models for liver cancer is crucial for developing new treatment technologies and strategies. The patient-derived xenograft (PDX) model preserves the tumor’s microenvironment and heterogeneity, which makes it advantageous for biological research, drug evaluation, personalized medicine, and other purposes. This article reviews the development, preparation techniques, application fields, and challenges of PDX models in liver cancer, providing insights for the research and exploration of PDX models in diagnostic and therapeutic strategies of liver cancer.http://journals.lww.com/10.1097/CM9.0000000000003480 |
| spellingShingle | Shuangshuang Dou Yunfei Huo Minghui Gao Quanwei Li Buxin Kou Mengyin Chai Xiaoni Liu Yanjie Yin Patient-derived xenograft model: Applications and challenges in liver cancer Chinese Medical Journal |
| title | Patient-derived xenograft model: Applications and challenges in liver cancer |
| title_full | Patient-derived xenograft model: Applications and challenges in liver cancer |
| title_fullStr | Patient-derived xenograft model: Applications and challenges in liver cancer |
| title_full_unstemmed | Patient-derived xenograft model: Applications and challenges in liver cancer |
| title_short | Patient-derived xenograft model: Applications and challenges in liver cancer |
| title_sort | patient derived xenograft model applications and challenges in liver cancer |
| url | http://journals.lww.com/10.1097/CM9.0000000000003480 |
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