Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis
The fruits of Lycium ruthenicum Murr. (Solanaceae) are employed in ethnomedicine and used as a functional food. Their antioxidant, anti-aging, and hypolipidemic activities have been investigated in modern research. This study indicated that the ethanolic extract of the fruits of L. ruthenicum Murr....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1498280/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849766313633775616 |
|---|---|
| author | Boya Cui Lanying Liu Xinmeng Qiao Tao Shi Min Yin Shu Xu Xu Feng Yu Shan |
| author_facet | Boya Cui Lanying Liu Xinmeng Qiao Tao Shi Min Yin Shu Xu Xu Feng Yu Shan |
| author_sort | Boya Cui |
| collection | DOAJ |
| description | The fruits of Lycium ruthenicum Murr. (Solanaceae) are employed in ethnomedicine and used as a functional food. Their antioxidant, anti-aging, and hypolipidemic activities have been investigated in modern research. This study indicated that the ethanolic extract of the fruits of L. ruthenicum Murr. (LRM) improved oxidative and heat stress tolerance, reduced the accumulation of lipofuscin, and retarded the aging process in Caenorhabditis elegans (Rhabditidae). Furthermore, the pharyngeal pumping rate and body length decreased under LRM treatment. Moreover, metabolomic analysis and the DPClusO algorithm revealed that LRM regulated a series of lifespan-related pathways centered on glycine, serine, and threonine metabolism. These results suggest that LRM prolongs the lifespan of Caenorhabditis elegans via dietary restriction. Moreover, feruloyl putrescine, a kind of polyamine, was found in differential metabolites, which may be the metabolite of caffeoyl-spermidine in LRM. These findings from this exploratory study offer a new insight into the roles of L. ruthenicum in anti-aging activity as a functional food. |
| format | Article |
| id | doaj-art-15711635be7e47849ad0cd9c09b4d061 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-15711635be7e47849ad0cd9c09b4d0612025-08-20T03:04:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.14982801498280Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysisBoya Cui0Lanying Liu1Xinmeng Qiao2Tao Shi3Min Yin4Shu Xu5Xu Feng6Yu Shan7Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaNational Wolfberry Engineering Research Center, Institute of Wolfberry Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing, ChinaThe fruits of Lycium ruthenicum Murr. (Solanaceae) are employed in ethnomedicine and used as a functional food. Their antioxidant, anti-aging, and hypolipidemic activities have been investigated in modern research. This study indicated that the ethanolic extract of the fruits of L. ruthenicum Murr. (LRM) improved oxidative and heat stress tolerance, reduced the accumulation of lipofuscin, and retarded the aging process in Caenorhabditis elegans (Rhabditidae). Furthermore, the pharyngeal pumping rate and body length decreased under LRM treatment. Moreover, metabolomic analysis and the DPClusO algorithm revealed that LRM regulated a series of lifespan-related pathways centered on glycine, serine, and threonine metabolism. These results suggest that LRM prolongs the lifespan of Caenorhabditis elegans via dietary restriction. Moreover, feruloyl putrescine, a kind of polyamine, was found in differential metabolites, which may be the metabolite of caffeoyl-spermidine in LRM. These findings from this exploratory study offer a new insight into the roles of L. ruthenicum in anti-aging activity as a functional food.https://www.frontiersin.org/articles/10.3389/fphar.2025.1498280/fulldietary restrictionglycine, serine, and threonine metabolismlifespannematodespermidine |
| spellingShingle | Boya Cui Lanying Liu Xinmeng Qiao Tao Shi Min Yin Shu Xu Xu Feng Yu Shan Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis Frontiers in Pharmacology dietary restriction glycine, serine, and threonine metabolism lifespan nematode spermidine |
| title | Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis |
| title_full | Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis |
| title_fullStr | Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis |
| title_full_unstemmed | Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis |
| title_short | Anti-aging activities of an ethanolic extract of Lycium ruthenicum in Caenorhabditis elegans based on metabonomic analysis |
| title_sort | anti aging activities of an ethanolic extract of lycium ruthenicum in caenorhabditis elegans based on metabonomic analysis |
| topic | dietary restriction glycine, serine, and threonine metabolism lifespan nematode spermidine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1498280/full |
| work_keys_str_mv | AT boyacui antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT lanyingliu antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT xinmengqiao antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT taoshi antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT minyin antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT shuxu antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT xufeng antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis AT yushan antiagingactivitiesofanethanolicextractoflyciumruthenicumincaenorhabditiselegansbasedonmetabonomicanalysis |