CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian hamsters

CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian hamsters

Rapid development of coronavirus disease 2019 (COVID-19) vaccines and antiviral drugs have significantly reduced morbidity and mortality worldwide. Although most of the vaccines were developed initially with the ancestral Wuhan antigen, here, we report the development and immunological efficacy of a...

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Main Authors: Jyotsna Dandotiya, Neeta Adhikari, Manas Ranjan Tripathy, Kamini Jakhar, Sudipta Sonar, Dibya Ranjan Pati, Vibhu Kanchan, Varsha S. Prasad, Jitendra Kumar, Nitesh K. Senapati, Arti Bharmoria, Neeraj Rani, Monika Lakhanpal, CS. Patil, Nishan Singh, Lovely Khan, Lavit Jambu, Naveen K. Jain, Syed Khalid Ali, Priyanka Priyadarsiny, Amulya K. Panda, Rajesh Jain, Shailendra Mani, Sweety Samal, Amit Awasthi, Zaigham Abbas Rizvi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
CoviWall
COVID-19-vaccine
immunogenicity
hamster
Delta strain
Th1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1447962/full
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