Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes
Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptoma...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4365156 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308520129757184 |
|---|---|
| author | Jinling Zhang Zhehao Lv Deli Zhao Lili Liu Yong Wan Tingting Fan Huimin Li Ying Guan Bailu Liu Qi Yang |
| author_facet | Jinling Zhang Zhehao Lv Deli Zhao Lili Liu Yong Wan Tingting Fan Huimin Li Ying Guan Bailu Liu Qi Yang |
| author_sort | Jinling Zhang |
| collection | DOAJ |
| description | Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50%) with calcified plaques in at least one coronary segment (p<0.01); the prevalence rates of diffuse calcified plaques in the DM2 and non-DM2 groups were 31.6% and 4.7%, respectively (p<0.01). Plasma hs-CRP levels in DM2 with calcified plaques were higher compared with values obtained for the non-DM2 group (p<0.01). In conclusion, combination of coronary CTA and hs-CRP might improve risk stratification in symptomatic DM2 patients. |
| format | Article |
| id | doaj-art-1569bd028d3f422095c5e2fb397e10aa |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1569bd028d3f422095c5e2fb397e10aa2025-08-20T03:54:25ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/43651564365156Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 DiabetesJinling Zhang0Zhehao Lv1Deli Zhao2Lili Liu3Yong Wan4Tingting Fan5Huimin Li6Ying Guan7Bailu Liu8Qi Yang9Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of Radiology, Xuanwu Hospital, Beijing 100053, ChinaLittle is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50%) with calcified plaques in at least one coronary segment (p<0.01); the prevalence rates of diffuse calcified plaques in the DM2 and non-DM2 groups were 31.6% and 4.7%, respectively (p<0.01). Plasma hs-CRP levels in DM2 with calcified plaques were higher compared with values obtained for the non-DM2 group (p<0.01). In conclusion, combination of coronary CTA and hs-CRP might improve risk stratification in symptomatic DM2 patients.http://dx.doi.org/10.1155/2016/4365156 |
| spellingShingle | Jinling Zhang Zhehao Lv Deli Zhao Lili Liu Yong Wan Tingting Fan Huimin Li Ying Guan Bailu Liu Qi Yang Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes |
| title_full | Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes |
| title_fullStr | Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes |
| title_full_unstemmed | Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes |
| title_short | Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes |
| title_sort | coronary plaque characteristics assessed by 256 slice coronary ct angiography and association with high sensitivity c reactive protein in symptomatic patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/4365156 |
| work_keys_str_mv | AT jinlingzhang coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT zhehaolv coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT delizhao coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT lililiu coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT yongwan coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT tingtingfan coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT huiminli coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT yingguan coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT bailuliu coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes AT qiyang coronaryplaquecharacteristicsassessedby256slicecoronaryctangiographyandassociationwithhighsensitivitycreactiveproteininsymptomaticpatientswithtype2diabetes |