Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer
Adipose-derived exosomes (ADEs), a subtype of extracellular vesicles, are critical mediators of communication between adipose tissue and tumors, playing pivotal roles in cancer progression and therapeutic response. These nanoscale vesicles carry microRNAs, proteins, and lipids that influence tumor c...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2025.2547564 |
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| _version_ | 1849738750627676160 |
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| author | Changjian Wang Zhikun Zheng Chuangyan Wu Dan Zhang Yangchenxi Wang Sheng Zhang Geng Wang Rui Zhou |
| author_facet | Changjian Wang Zhikun Zheng Chuangyan Wu Dan Zhang Yangchenxi Wang Sheng Zhang Geng Wang Rui Zhou |
| author_sort | Changjian Wang |
| collection | DOAJ |
| description | Adipose-derived exosomes (ADEs), a subtype of extracellular vesicles, are critical mediators of communication between adipose tissue and tumors, playing pivotal roles in cancer progression and therapeutic response. These nanoscale vesicles carry microRNAs, proteins, and lipids that influence tumor cell proliferation, migration, metastasis, and immune modulation. The dual functions of ADEs – both in promoting and suppressing tumorigenesis – are largely dependent on their cellular origin, molecular cargo, and the characteristics of the tumor microenvironment. Recent studies have identified ADEs as potential diagnostic biomarkers, therapeutic targets, and drug delivery platforms, offering promising avenues for precision oncology. However, significant challenges – such as biological heterogeneity, lack of standardization in production, concerns regarding efficacy and safety, and regulatory constraints – continue to hinder their clinical translation. This review aimed to explore the multifaceted roles of ADEs in cancer pathogenesis, their therapeutic potential, and current limitations, providing insights to guide future research and clinical applications. |
| format | Article |
| id | doaj-art-1568ee0c597c4c8c8c14c38fcd9d2f60 |
| institution | DOAJ |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-1568ee0c597c4c8c8c14c38fcd9d2f602025-08-20T03:06:28ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762025-12-0126110.1080/15384047.2025.2547564Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancerChangjian Wang0Zhikun Zheng1Chuangyan Wu2Dan Zhang3Yangchenxi Wang4Sheng Zhang5Geng Wang6Rui Zhou7Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAdipose-derived exosomes (ADEs), a subtype of extracellular vesicles, are critical mediators of communication between adipose tissue and tumors, playing pivotal roles in cancer progression and therapeutic response. These nanoscale vesicles carry microRNAs, proteins, and lipids that influence tumor cell proliferation, migration, metastasis, and immune modulation. The dual functions of ADEs – both in promoting and suppressing tumorigenesis – are largely dependent on their cellular origin, molecular cargo, and the characteristics of the tumor microenvironment. Recent studies have identified ADEs as potential diagnostic biomarkers, therapeutic targets, and drug delivery platforms, offering promising avenues for precision oncology. However, significant challenges – such as biological heterogeneity, lack of standardization in production, concerns regarding efficacy and safety, and regulatory constraints – continue to hinder their clinical translation. This review aimed to explore the multifaceted roles of ADEs in cancer pathogenesis, their therapeutic potential, and current limitations, providing insights to guide future research and clinical applications.https://www.tandfonline.com/doi/10.1080/15384047.2025.2547564Adipose-derived exosomescanceradipose tissuetumor microenvironmentmiRNAexosome-based therapy |
| spellingShingle | Changjian Wang Zhikun Zheng Chuangyan Wu Dan Zhang Yangchenxi Wang Sheng Zhang Geng Wang Rui Zhou Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer Cancer Biology & Therapy Adipose-derived exosomes cancer adipose tissue tumor microenvironment miRNA exosome-based therapy |
| title | Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer |
| title_full | Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer |
| title_fullStr | Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer |
| title_full_unstemmed | Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer |
| title_short | Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer |
| title_sort | adipose derived exosomes mediators of crosstalk between adipose tissue and cancer |
| topic | Adipose-derived exosomes cancer adipose tissue tumor microenvironment miRNA exosome-based therapy |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2025.2547564 |
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