RobusTAD: reference panel based annotation of nested topologically associating domains

RobusTAD: reference panel based annotation of nested topologically associating domains

Abstract Topologically associating domains (TADs) are fundamental units of 3D genomes and play essential roles in gene regulation. Hi-C data suggests a hierarchical organization of TADs. Accurately annotating nested TADs from Hi-C data remains challenging, both in terms of the precise identification...

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Bibliographic Details
Main Authors: Yanlin Zhang, Rola Dali, Mathieu Blanchette
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Biology
Subjects:
Hi-C
TAD
Nonparametric test
Dynamic programming
Online Access:https://doi.org/10.1186/s13059-025-03568-9
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