Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress

Dehydration response element binding proteins (DREBs) play a vital role in transcriptional regulators in enhancing plant tolerance to abiotic stress. To investigate the biological functions of the DREB gene family (SiDREBs) in foxtail millet (Setaria italica), this study performed bioinformatics and...

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Main Authors: Yanan Yang, Yun Li, Zhenqing Guo, Yuxue Zhao, Xiaoke Zhou, Yucui Han, Xiaohu Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Plant Science
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Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2025.1552120/full
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author Yanan Yang
Yun Li
Zhenqing Guo
Yuxue Zhao
Xiaoke Zhou
Yucui Han
Xiaohu Lin
author_facet Yanan Yang
Yun Li
Zhenqing Guo
Yuxue Zhao
Xiaoke Zhou
Yucui Han
Xiaohu Lin
author_sort Yanan Yang
collection DOAJ
description Dehydration response element binding proteins (DREBs) play a vital role in transcriptional regulators in enhancing plant tolerance to abiotic stress. To investigate the biological functions of the DREB gene family (SiDREBs) in foxtail millet (Setaria italica), this study performed bioinformatics and gene expression analysis on SiDREBs under abiotic stress. A total of 166 family members of SiDREBs were identified, which were classified into six subfamilies. SiDREBs were unevenly distributed on nine chromosomes, and were designated as SiDREB1–166 based on their chromosomal positions. Covariance analysis revealed that SiDREBs were much more closely related to monocotyledonous plants sorghum, maize, and rice than to dicotyledonous plants Arabidopsis thaliana, tomato, and soybean. Promoter cis-acting element analysis showed that SiDREBs contained stress-related cis-acting elements. Under saline-alkali stress, SiDREB153 exhibited significantly different expression levels between the resistant and susceptible materials, indicating that it plays a positive regulatory role in the response of foxtail millet to saline-alkali stress. Among different abiotic stresses, the expression of SiDREB80 increased under drought, saline-alkali, and shade stress, that of SiDREB4/129/131 rose under saline-alkali and high temperature stress, and that of SiDREB159 increased under herbicide and saline-alkali stress. These genes play an important role in the response of foxtail millet to stress. These findings provide a theoretical basis for further studies on the function of SiDREBs in response to abiotic stress.
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spelling doaj-art-15674e517c6e4e1b876142e1a209c97c2025-08-20T02:19:58ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2025-04-011610.3389/fpls.2025.15521201552120Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stressYanan Yang0Yun Li1Zhenqing Guo2Yuxue Zhao3Xiaoke Zhou4Yucui Han5Xiaohu Lin6College of Agronomy and Biotechnology/Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaResearch Center of Rural Vitalization, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaCollege of Agronomy and Biotechnology/Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaCollege of Agronomy and Biotechnology/Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaCollege of Agronomy and Biotechnology/Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaCollege of Agronomy and Biotechnology/Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaCollege of Agronomy and Biotechnology/Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, ChinaDehydration response element binding proteins (DREBs) play a vital role in transcriptional regulators in enhancing plant tolerance to abiotic stress. To investigate the biological functions of the DREB gene family (SiDREBs) in foxtail millet (Setaria italica), this study performed bioinformatics and gene expression analysis on SiDREBs under abiotic stress. A total of 166 family members of SiDREBs were identified, which were classified into six subfamilies. SiDREBs were unevenly distributed on nine chromosomes, and were designated as SiDREB1–166 based on their chromosomal positions. Covariance analysis revealed that SiDREBs were much more closely related to monocotyledonous plants sorghum, maize, and rice than to dicotyledonous plants Arabidopsis thaliana, tomato, and soybean. Promoter cis-acting element analysis showed that SiDREBs contained stress-related cis-acting elements. Under saline-alkali stress, SiDREB153 exhibited significantly different expression levels between the resistant and susceptible materials, indicating that it plays a positive regulatory role in the response of foxtail millet to saline-alkali stress. Among different abiotic stresses, the expression of SiDREB80 increased under drought, saline-alkali, and shade stress, that of SiDREB4/129/131 rose under saline-alkali and high temperature stress, and that of SiDREB159 increased under herbicide and saline-alkali stress. These genes play an important role in the response of foxtail millet to stress. These findings provide a theoretical basis for further studies on the function of SiDREBs in response to abiotic stress.https://www.frontiersin.org/articles/10.3389/fpls.2025.1552120/fullfoxtail milletDREBgene familyabiotic stressgene expression
spellingShingle Yanan Yang
Yun Li
Zhenqing Guo
Yuxue Zhao
Xiaoke Zhou
Yucui Han
Xiaohu Lin
Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress
Frontiers in Plant Science
foxtail millet
DREB
gene family
abiotic stress
gene expression
title Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress
title_full Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress
title_fullStr Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress
title_full_unstemmed Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress
title_short Identification of DREB gene family in foxtail millet (Setaria italica) and analysis of its expression pattern in response to abiotic stress
title_sort identification of dreb gene family in foxtail millet setaria italica and analysis of its expression pattern in response to abiotic stress
topic foxtail millet
DREB
gene family
abiotic stress
gene expression
url https://www.frontiersin.org/articles/10.3389/fpls.2025.1552120/full
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