Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep
Interregional interactions of oscillatory activity are crucial for the integrated processing of multiple brain regions. However, while the EEG in virtually all brain structures passes through substantial modifications during sleep, it is still an open question whether interactions between neocortica...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2008/563028 |
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| author | Nikolai Axmacher Christoph Helmstaedter Christian E. Elger Juergen Fell |
| author_facet | Nikolai Axmacher Christoph Helmstaedter Christian E. Elger Juergen Fell |
| author_sort | Nikolai Axmacher |
| collection | DOAJ |
| description | Interregional interactions of oscillatory activity are crucial for the integrated processing of multiple brain regions. However, while the EEG in virtually all brain structures passes through substantial modifications during sleep, it is still an open question whether interactions between neocortical and medial temporal EEG oscillations also depend on the state of alertness. Several previous studies in animals and humans suggest that hippocampal-neocortical interactions crucially depend on the state of alertness (i.e., waking state or sleep). Here, we analyzed scalp and intracranial EEG recordings during sleep and waking state in epilepsy patients undergoing presurgical evaluation. We found that the amplitudes of oscillations within the medial temporal lobe and the neocortex were more closely correlated during sleep, in particular during non-REM sleep, than during waking state. Possibly, the encoding of novel sensory inputs, which mainly occurs during waking state, requires that medial temporal dynamics are rather independent from neocortical dynamics, while the consolidation of memories during sleep may demand closer interactions between MTL and neocortex. |
| format | Article |
| id | doaj-art-15660ee1aec84428999b56b6a5107635 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-15660ee1aec84428999b56b6a51076352025-02-03T01:11:28ZengWileyNeural Plasticity2090-59041687-54432008-01-01200810.1155/2008/563028563028Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM SleepNikolai Axmacher0Christoph Helmstaedter1Christian E. Elger2Juergen Fell3Department of Epileptology, University of Bonn, 53105 Bonn, GermanyDepartment of Epileptology, University of Bonn, 53105 Bonn, GermanyDepartment of Epileptology, University of Bonn, 53105 Bonn, GermanyDepartment of Epileptology, University of Bonn, 53105 Bonn, GermanyInterregional interactions of oscillatory activity are crucial for the integrated processing of multiple brain regions. However, while the EEG in virtually all brain structures passes through substantial modifications during sleep, it is still an open question whether interactions between neocortical and medial temporal EEG oscillations also depend on the state of alertness. Several previous studies in animals and humans suggest that hippocampal-neocortical interactions crucially depend on the state of alertness (i.e., waking state or sleep). Here, we analyzed scalp and intracranial EEG recordings during sleep and waking state in epilepsy patients undergoing presurgical evaluation. We found that the amplitudes of oscillations within the medial temporal lobe and the neocortex were more closely correlated during sleep, in particular during non-REM sleep, than during waking state. Possibly, the encoding of novel sensory inputs, which mainly occurs during waking state, requires that medial temporal dynamics are rather independent from neocortical dynamics, while the consolidation of memories during sleep may demand closer interactions between MTL and neocortex.http://dx.doi.org/10.1155/2008/563028 |
| spellingShingle | Nikolai Axmacher Christoph Helmstaedter Christian E. Elger Juergen Fell Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep Neural Plasticity |
| title | Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep |
| title_full | Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep |
| title_fullStr | Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep |
| title_full_unstemmed | Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep |
| title_short | Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep |
| title_sort | enhancement of neocortical medial temporal eeg correlations during non rem sleep |
| url | http://dx.doi.org/10.1155/2008/563028 |
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