Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery
Overweight and obesity represent major risk factors for diabetes and related metabolic diseases. Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating th...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2016/4390254 |
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| _version_ | 1849308518669090816 |
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| author | Olivier F. Noel Christopher D. Still George Argyropoulos Michael Edwards Glenn S. Gerhard |
| author_facet | Olivier F. Noel Christopher D. Still George Argyropoulos Michael Edwards Glenn S. Gerhard |
| author_sort | Olivier F. Noel |
| collection | DOAJ |
| description | Overweight and obesity represent major risk factors for diabetes and related metabolic diseases. Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating this inflammatory process remains poorly understood. The most effective intervention for the treatment of obesity, bariatric surgery, leads to glucose normalization and remission of T2D. Recent work in both clinical studies and animal models supports bile acids (BAs) as key mediators of these effects. BAs are involved in lipid and glucose homeostasis primarily via the farnesoid X receptor (FXR) transcription factor. BAs are also involved in regulating genes involved in inflammation, obesity, and lipid metabolism. Here, we review the novel role of BAs in bariatric surgery and the intersection between BAs and immune, obesity, weight loss, and lipid metabolism genes. |
| format | Article |
| id | doaj-art-1563d5ca66074c20a2deacff68bd52dd |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-1563d5ca66074c20a2deacff68bd52dd2025-08-20T03:54:25ZengWileyJournal of Obesity2090-07082090-07162016-01-01201610.1155/2016/43902544390254Bile Acids, FXR, and Metabolic Effects of Bariatric SurgeryOlivier F. Noel0Christopher D. Still1George Argyropoulos2Michael Edwards3Glenn S. Gerhard4Temple University School of Medicine, Philadelphia, PA 19140, USAGeisinger Clinic, Danville, PA 17822, USAGeisinger Clinic, Danville, PA 17822, USATemple University School of Medicine, Philadelphia, PA 19140, USATemple University School of Medicine, Philadelphia, PA 19140, USAOverweight and obesity represent major risk factors for diabetes and related metabolic diseases. Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating this inflammatory process remains poorly understood. The most effective intervention for the treatment of obesity, bariatric surgery, leads to glucose normalization and remission of T2D. Recent work in both clinical studies and animal models supports bile acids (BAs) as key mediators of these effects. BAs are involved in lipid and glucose homeostasis primarily via the farnesoid X receptor (FXR) transcription factor. BAs are also involved in regulating genes involved in inflammation, obesity, and lipid metabolism. Here, we review the novel role of BAs in bariatric surgery and the intersection between BAs and immune, obesity, weight loss, and lipid metabolism genes.http://dx.doi.org/10.1155/2016/4390254 |
| spellingShingle | Olivier F. Noel Christopher D. Still George Argyropoulos Michael Edwards Glenn S. Gerhard Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery Journal of Obesity |
| title | Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery |
| title_full | Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery |
| title_fullStr | Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery |
| title_full_unstemmed | Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery |
| title_short | Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery |
| title_sort | bile acids fxr and metabolic effects of bariatric surgery |
| url | http://dx.doi.org/10.1155/2016/4390254 |
| work_keys_str_mv | AT olivierfnoel bileacidsfxrandmetaboliceffectsofbariatricsurgery AT christopherdstill bileacidsfxrandmetaboliceffectsofbariatricsurgery AT georgeargyropoulos bileacidsfxrandmetaboliceffectsofbariatricsurgery AT michaeledwards bileacidsfxrandmetaboliceffectsofbariatricsurgery AT glennsgerhard bileacidsfxrandmetaboliceffectsofbariatricsurgery |