Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions
Purpose: to evaluate the effectiveness and safety of complex therapy in patients with demodex blepharitis and dry eye. Methods. 25 patients with mixed demodex blepharitis and dry eye (50 eyes; 10 men, 15 women; 61.9 ± 5.6 years) were examined before and after treatment with 0.5 % levofloxacin instil...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2024-07-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/1487 |
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| author | S. N. Sakhnov S. V. Yanchenko A. V. Malyshev S. J. Teshaev G. R. Odilova N. Yu. Khuddieva N. O. Murodullaeva |
| author_facet | S. N. Sakhnov S. V. Yanchenko A. V. Malyshev S. J. Teshaev G. R. Odilova N. Yu. Khuddieva N. O. Murodullaeva |
| author_sort | S. N. Sakhnov |
| collection | DOAJ |
| description | Purpose: to evaluate the effectiveness and safety of complex therapy in patients with demodex blepharitis and dry eye. Methods. 25 patients with mixed demodex blepharitis and dry eye (50 eyes; 10 men, 15 women; 61.9 ± 5.6 years) were examined before and after treatment with 0.5 % levofloxacin instillation (5 times a day, 5 days); sulfur and metronidazole gel applications (Blefarogel-forte) as part of therapeutic eyelid hygiene (Blepharogel-cleansing, Blepharolotion; starting from day 6, 2 times a day, 45 days); 0.24 % sodium hyaluronate instillation (3 times a day). Therapy effectiveness criteria were as follows: D. folliculorum mite population reduction; positive dynamics of blepharitis objective signs and meibomian gland dysfunction severity (MGD-S, points). Therapy safety criteria included the absence of negative dynamics of OSDI, tear film breakup time (TBUT, s), inferior tear meniscus height (ITMH, µm) and xerosis index (XI, points). Results. As a result of the therapy, statistically significant changes were noted, including mite population reduction (from 9.23 ± 0.81 to 3.54 ± 0.80 imagos); eyelid margins edema intensity decrease (from 3.18 ± 0.39 to 1.30 ± 0.45 points) and hyperemia decrease (from 2.90 ± 0.29 to 0.9 ± 0.3 points); MGD-S decrease (from 2.1 ± 0.3 to 0.95 ± 0.21 points); OSDI decrease (from 43.23 ± 4.70 to 25.10 ± 2.65 points); TBUT increase (from 4.05 ± 0.50 to 5.55 ± 0.50 s); XI decrease (from 5.36 ± 0.49 to 4.04 ± 0.60 points). Conclusion. The treatment of demodex blepharitis and dry eye treatment, including sulfur and metronidazole gel applications, therapeutic eyelid hygiene and 0.5 % levofloxacin and 0.24 % sodium hyaluronate instillation demonstrated a high efficiency and a good safety profile. |
| format | Article |
| id | doaj-art-156273f869334fb199ec8c7ad07fb00a |
| institution | Kabale University |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2024-07-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-156273f869334fb199ec8c7ad07fb00a2025-08-20T03:39:28ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602024-07-01172323710.21516/2072-0076-2024-17-2-32-37684Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditionsS. N. Sakhnov0S. V. Yanchenko1A. V. Malyshev2S. J. Teshaev3G. R. Odilova4N. Yu. Khuddieva5N. O. Murodullaeva6Kuban State Medical UniversityAbu Ali ibn Sino Bukhara State Medical InstituteKuban State Medical University; S.V. Ochapovsky Regional Clinic Hospital #1Abu Ali ibn Sino Bukhara State Medical InstituteAbu Ali ibn Sino Bukhara State Medical InstituteAbu Ali ibn Sino Bukhara State Medical InstituteAbu Ali ibn Sino Bukhara State Medical InstitutePurpose: to evaluate the effectiveness and safety of complex therapy in patients with demodex blepharitis and dry eye. Methods. 25 patients with mixed demodex blepharitis and dry eye (50 eyes; 10 men, 15 women; 61.9 ± 5.6 years) were examined before and after treatment with 0.5 % levofloxacin instillation (5 times a day, 5 days); sulfur and metronidazole gel applications (Blefarogel-forte) as part of therapeutic eyelid hygiene (Blepharogel-cleansing, Blepharolotion; starting from day 6, 2 times a day, 45 days); 0.24 % sodium hyaluronate instillation (3 times a day). Therapy effectiveness criteria were as follows: D. folliculorum mite population reduction; positive dynamics of blepharitis objective signs and meibomian gland dysfunction severity (MGD-S, points). Therapy safety criteria included the absence of negative dynamics of OSDI, tear film breakup time (TBUT, s), inferior tear meniscus height (ITMH, µm) and xerosis index (XI, points). Results. As a result of the therapy, statistically significant changes were noted, including mite population reduction (from 9.23 ± 0.81 to 3.54 ± 0.80 imagos); eyelid margins edema intensity decrease (from 3.18 ± 0.39 to 1.30 ± 0.45 points) and hyperemia decrease (from 2.90 ± 0.29 to 0.9 ± 0.3 points); MGD-S decrease (from 2.1 ± 0.3 to 0.95 ± 0.21 points); OSDI decrease (from 43.23 ± 4.70 to 25.10 ± 2.65 points); TBUT increase (from 4.05 ± 0.50 to 5.55 ± 0.50 s); XI decrease (from 5.36 ± 0.49 to 4.04 ± 0.60 points). Conclusion. The treatment of demodex blepharitis and dry eye treatment, including sulfur and metronidazole gel applications, therapeutic eyelid hygiene and 0.5 % levofloxacin and 0.24 % sodium hyaluronate instillation demonstrated a high efficiency and a good safety profile.https://roj.igb.ru/jour/article/view/1487blepharitisdemodexdry eyeeyelid hygiene |
| spellingShingle | S. N. Sakhnov S. V. Yanchenko A. V. Malyshev S. J. Teshaev G. R. Odilova N. Yu. Khuddieva N. O. Murodullaeva Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions Российский офтальмологический журнал blepharitis demodex dry eye eyelid hygiene |
| title | Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions |
| title_full | Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions |
| title_fullStr | Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions |
| title_full_unstemmed | Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions |
| title_short | Effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions |
| title_sort | effectiveness and safety of demodecosis blepharitis therapy under dry eye conditions |
| topic | blepharitis demodex dry eye eyelid hygiene |
| url | https://roj.igb.ru/jour/article/view/1487 |
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