Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) represents a major global health burden due to its high recurrence and mortality rates. For patients with advanced HCC and compromised liver function, Pharmacotherapy has become the primary approach due to the limited efficacy of conventional treatments (e.g., surgical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1673134/full |
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| author | Xun Liao Junxiu Zhou Liang Feng Lian Wang Hong Wu Li Jiang Yuanyuan Jia Qingbin Wu Shu Shen |
| author_facet | Xun Liao Junxiu Zhou Liang Feng Lian Wang Hong Wu Li Jiang Yuanyuan Jia Qingbin Wu Shu Shen |
| author_sort | Xun Liao |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) represents a major global health burden due to its high recurrence and mortality rates. For patients with advanced HCC and compromised liver function, Pharmacotherapy has become the primary approach due to the limited efficacy of conventional treatments (e.g., surgical resection/ablation). Nevertheless, traditional anti-tumor agents suffer from poor target selectivity, systemic toxicity, and the emergence of drug resistance. To overcome these challenges, stimuli-responsive biomaterials have been developed as innovative strategies to improve HCC management. These advanced materials enable precise spatiotemporal control of drug delivery and release, thereby enhancing therapeutic efficacy while reducing side effects. This review provides a systematic overview of stimuli-responsive biomaterials, classified based on their responses to endogenous cues (e.g., pH, enzymes, and redox conditions) and exogenous stimuli (e.g., light and magnetic fields). These materials show great potential in overcoming biological barriers in HCC therapy and enhancing drug delivery efficiency, thereby paving the way for future clinical applications. By analyzing recent advances, this review highlights the potential of stimuli-responsive biomaterials in advancing therapeutic strategies for HCC. Integrating these materials into HCC therapy may significantly enhance patient outcomes and revolutionize existing treatment paradigms. |
| format | Article |
| id | doaj-art-156099fd2e98465783b4616bb8076d57 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-156099fd2e98465783b4616bb8076d572025-08-20T05:33:01ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-08-011310.3389/fbioe.2025.16731341673134Responsive biomaterials for therapeutic strategies of hepatocellular carcinomaXun Liao0Junxiu Zhou1Liang Feng2Lian Wang3Hong Wu4Li Jiang5Yuanyuan Jia6Qingbin Wu7Shu Shen8Tianfu Jincheng Laboratory, Chengdu, ChinaTianfu Jincheng Laboratory, Chengdu, ChinaTianfu Jincheng Laboratory, Chengdu, ChinaTianfu Jincheng Laboratory, Chengdu, ChinaTianfu Jincheng Laboratory, Chengdu, ChinaTianfu Jincheng Laboratory, Chengdu, ChinaTianfu Jincheng Laboratory, Chengdu, ChinaColorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, ChinaHepatocellular carcinoma (HCC) represents a major global health burden due to its high recurrence and mortality rates. For patients with advanced HCC and compromised liver function, Pharmacotherapy has become the primary approach due to the limited efficacy of conventional treatments (e.g., surgical resection/ablation). Nevertheless, traditional anti-tumor agents suffer from poor target selectivity, systemic toxicity, and the emergence of drug resistance. To overcome these challenges, stimuli-responsive biomaterials have been developed as innovative strategies to improve HCC management. These advanced materials enable precise spatiotemporal control of drug delivery and release, thereby enhancing therapeutic efficacy while reducing side effects. This review provides a systematic overview of stimuli-responsive biomaterials, classified based on their responses to endogenous cues (e.g., pH, enzymes, and redox conditions) and exogenous stimuli (e.g., light and magnetic fields). These materials show great potential in overcoming biological barriers in HCC therapy and enhancing drug delivery efficiency, thereby paving the way for future clinical applications. By analyzing recent advances, this review highlights the potential of stimuli-responsive biomaterials in advancing therapeutic strategies for HCC. Integrating these materials into HCC therapy may significantly enhance patient outcomes and revolutionize existing treatment paradigms.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1673134/fullhepatocellular carcinoma (HCC)responsive biomaterialsdrug deliverytumor microenvironmentcancer therapy |
| spellingShingle | Xun Liao Junxiu Zhou Liang Feng Lian Wang Hong Wu Li Jiang Yuanyuan Jia Qingbin Wu Shu Shen Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma Frontiers in Bioengineering and Biotechnology hepatocellular carcinoma (HCC) responsive biomaterials drug delivery tumor microenvironment cancer therapy |
| title | Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma |
| title_full | Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma |
| title_fullStr | Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma |
| title_full_unstemmed | Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma |
| title_short | Responsive biomaterials for therapeutic strategies of hepatocellular carcinoma |
| title_sort | responsive biomaterials for therapeutic strategies of hepatocellular carcinoma |
| topic | hepatocellular carcinoma (HCC) responsive biomaterials drug delivery tumor microenvironment cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1673134/full |
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