Ameliorative effects of Berberine chloride against 5-fluorouracil-induced cardiotoxicity in Sprague Dawley rats

Ameliorative effects of Berberine chloride against 5-fluorouracil-induced cardiotoxicity in Sprague Dawley rats

Abstract 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic agent for solid malignancies. Although it has crucial therapeutic effects, it ranks as the second most cardiotoxic antineoplastic agent. Berberine (BBR) is a quaternary benzylisoquinoline alkaloid with promising antioxidant pr...

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Bibliographic Details
Main Authors: Mirna Akram Labib, Omar S. Saeed, Samar H. ElSharkawy, Marwa S. Khattab, Hesham Y. El-Zorba, Khaled Abo-EL-Sooud
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
5-Fluorouracil
Berberine
Cardiotoxicity
Antioxidant
ECG
Gene expression
Online Access:https://doi.org/10.1038/s41598-025-12389-6
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