Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies
Copper is an essential micronutrient involved in various physiological processes in various cell types. Consequently, dysregulation of copper homeostasis—either excessive or deficient—can lead to pathological changes, such as heart failure (HF). Recently, a new type of copper-dependent cell death kn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1527901/full |
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| author | Zhichao Liu Yongkang Gan Zhen Shen Siqi Cai Xizhen Wang Yong Li Xiaofeng Li Huanjie Fu Jinhong Chen Ningcen Li |
| author_facet | Zhichao Liu Yongkang Gan Zhen Shen Siqi Cai Xizhen Wang Yong Li Xiaofeng Li Huanjie Fu Jinhong Chen Ningcen Li |
| author_sort | Zhichao Liu |
| collection | DOAJ |
| description | Copper is an essential micronutrient involved in various physiological processes in various cell types. Consequently, dysregulation of copper homeostasis—either excessive or deficient—can lead to pathological changes, such as heart failure (HF). Recently, a new type of copper-dependent cell death known as cuproptosis has drawn increasing attention to the impact of copper dyshomeostasis on HF. Notably, copper dyshomeostasis was associated with the occurrence of HF. Hence, this review aimed to investigate the biological processes involved in copper uptake, transport, excretion, and storage at both the cellular and systemic levels in terms of cuproptosis and HF, along with the underlying mechanisms of action. Additionally, the role of cuproptosis and its related mitochondrial dysfunction in HF pathogenesis was analyzed. Finally, we reviewed the therapeutic potential of current drugs that target copper metabolism for treating HF. Overall, the conclusions of this review revealed the therapeutic potential of copper-based therapies that target cuproptosis for the development of strategies for the treatment of HF. |
| format | Article |
| id | doaj-art-155cb2126c604164bf9392da73af6d79 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-155cb2126c604164bf9392da73af6d792025-01-09T06:10:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15279011527901Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategiesZhichao Liu0Yongkang Gan1Zhen Shen2Siqi Cai3Xizhen Wang4Yong Li5Xiaofeng Li6Huanjie Fu7Jinhong Chen8Ningcen Li9School of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Vascular Surgery, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, ChinaCollege of Art, Nanjing University of Information Science and Technology, Nanjing, Jiangsu, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaExperimental Center for Medical Research, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Cardiovascular, Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Cardiovascular, Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCopper is an essential micronutrient involved in various physiological processes in various cell types. Consequently, dysregulation of copper homeostasis—either excessive or deficient—can lead to pathological changes, such as heart failure (HF). Recently, a new type of copper-dependent cell death known as cuproptosis has drawn increasing attention to the impact of copper dyshomeostasis on HF. Notably, copper dyshomeostasis was associated with the occurrence of HF. Hence, this review aimed to investigate the biological processes involved in copper uptake, transport, excretion, and storage at both the cellular and systemic levels in terms of cuproptosis and HF, along with the underlying mechanisms of action. Additionally, the role of cuproptosis and its related mitochondrial dysfunction in HF pathogenesis was analyzed. Finally, we reviewed the therapeutic potential of current drugs that target copper metabolism for treating HF. Overall, the conclusions of this review revealed the therapeutic potential of copper-based therapies that target cuproptosis for the development of strategies for the treatment of HF.https://www.frontiersin.org/articles/10.3389/fphar.2024.1527901/fullcoppercopper homeostasiscuproptosismitochondrionheart failure |
| spellingShingle | Zhichao Liu Yongkang Gan Zhen Shen Siqi Cai Xizhen Wang Yong Li Xiaofeng Li Huanjie Fu Jinhong Chen Ningcen Li Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies Frontiers in Pharmacology copper copper homeostasis cuproptosis mitochondrion heart failure |
| title | Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies |
| title_full | Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies |
| title_fullStr | Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies |
| title_full_unstemmed | Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies |
| title_short | Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies |
| title_sort | role of copper homeostasis and cuproptosis in heart failure pathogenesis implications for therapeutic strategies |
| topic | copper copper homeostasis cuproptosis mitochondrion heart failure |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1527901/full |
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