Rapid and sustainable deep testosterone reduction predicts effective androgen deprivation therapy for metastatic hormone-sensitive prostate cancer

Rapid and sustainable deep testosterone reduction predicts effective androgen deprivation therapy for metastatic hormone-sensitive prostate cancer

Abstract The testosterone (TT)/androgen receptor axis plays a crucial role in the initiation and progression of prostate cancer (PCa). We aimed to investigate the predictive value of serum TT levels on metastatic PCa progression. A total of 219 patients with metastatic PCa were included in this stud...

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Bibliographic Details
Main Authors: Ze Wang, Haiyang Xiao, Chongliang Zheng, Jian Chen, Qiming Chen, Zhenzhen Chen, Dianzheng Zhang, Luofu Wang, Weihua Lan, Qiuli Liu, Jun Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Metastatic prostate cancer
Androgen deprivation therapy
Deep testosterone reduction
Castration-resistant
PSA progression
Online Access:https://doi.org/10.1038/s41598-025-13480-8
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