Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers
The combination of Polycaprolactone (PCL), Poly (lactic-co-glycolic acid) (PLGA), and hyaluronic acid (HA) in nanofiber formulations offers a synergistic approach for the development of advanced biomaterials. Understanding the inherent limitations of individual polymers and the modification of key p...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Next Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949822825002473 |
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| author | Peace-OfonAbasi O. Bassey Bukola A. Oseni Deborah A. Ogundemuren Karamot O. Oyediran Evans N. Ekeji Dimitrios Tsamos Alkiviadis Tsamis Alexandros E. Tsouknidas Bryan C. Okwuba David A. Vorp Samson A. Adeosun Margaret O. Ilomuanya |
| author_facet | Peace-OfonAbasi O. Bassey Bukola A. Oseni Deborah A. Ogundemuren Karamot O. Oyediran Evans N. Ekeji Dimitrios Tsamos Alkiviadis Tsamis Alexandros E. Tsouknidas Bryan C. Okwuba David A. Vorp Samson A. Adeosun Margaret O. Ilomuanya |
| author_sort | Peace-OfonAbasi O. Bassey |
| collection | DOAJ |
| description | The combination of Polycaprolactone (PCL), Poly (lactic-co-glycolic acid) (PLGA), and hyaluronic acid (HA) in nanofiber formulations offers a synergistic approach for the development of advanced biomaterials. Understanding the inherent limitations of individual polymers and the modification of key parameters in nanofiber production is crucial for fabricating composite electrospun fibers especially for the purpose of contraception. This study investigates the microstructural characteristics, and mechanical properties of PCL/PLGA/HA loaded Levonorgestrel (LNG) nanofibers for contraception. PCL, PLGA, and HA were mixed in suitable diluents at a ratio of 3:2:1. Levonorgestrel was added to the polymer blend. PCL/PLGA/HA was electrospun with surfactant sodium cocoamphoacetate (CAP) and an outer layer of HA was electrosprayed in the same proportion as stated above. Eight nanofiber samples were fabricated, each varying in collector type, presence of LNG, and additional treatments with CAP. The mean diameter of samples ranged from 6.28 ± 0.27 pix to 5.38 ± 0.07 pix. The tensile strength, Young’s modulus and elongation at break were also determined. This study showed the relationship between formulation and processing parameters and the resulting fiber characteristics via image-based analysis and mechanical testing, highlighting the potential for precise control over nanofiber properties for tailoring nanofiber mats for delivery of Levonorgestrel in contraception. |
| format | Article |
| id | doaj-art-1555ee62b2aa44238aee9c8478e3d677 |
| institution | OA Journals |
| issn | 2949-8228 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Materials |
| spelling | doaj-art-1555ee62b2aa44238aee9c8478e3d6772025-08-20T02:33:15ZengElsevierNext Materials2949-82282025-07-01810072910.1016/j.nxmate.2025.100729Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibersPeace-OfonAbasi O. Bassey0Bukola A. Oseni1Deborah A. Ogundemuren2Karamot O. Oyediran3Evans N. Ekeji4Dimitrios Tsamos5Alkiviadis Tsamis6Alexandros E. Tsouknidas7Bryan C. Okwuba8David A. Vorp9Samson A. Adeosun10Margaret O. Ilomuanya11Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, NigeriaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, NigeriaDepartment of Mechanical Engineering, University of Western Macedonia, Kozani 50100, GreeceDepartment of Mechanical Engineering, University of Western Macedonia, Kozani 50100, Greece; School of Engineering, University of Leicester, Leicester LE1 7RH, United KingdomDepartment of Mechanical Engineering, University of Western Macedonia, Kozani 50100, GreeceDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, NigeriaDepartments of Bioengineering, Surgery, Cardiothoracic Surgery, Mechanical Engineering & Materials Science, Chemical and Petroleum Engineering, McGowan Institute for Regenerative Medicine, Clinical & Translational Sciences Institute, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Metallurgical and Materials Engineering, Faculty of Engineering, University of Lagos, Lagos, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria; MEDAFRICA GMP Laboratory, Faculty of Pharmacy, University of Lagos, Nigeria; Corresponding author at: Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.The combination of Polycaprolactone (PCL), Poly (lactic-co-glycolic acid) (PLGA), and hyaluronic acid (HA) in nanofiber formulations offers a synergistic approach for the development of advanced biomaterials. Understanding the inherent limitations of individual polymers and the modification of key parameters in nanofiber production is crucial for fabricating composite electrospun fibers especially for the purpose of contraception. This study investigates the microstructural characteristics, and mechanical properties of PCL/PLGA/HA loaded Levonorgestrel (LNG) nanofibers for contraception. PCL, PLGA, and HA were mixed in suitable diluents at a ratio of 3:2:1. Levonorgestrel was added to the polymer blend. PCL/PLGA/HA was electrospun with surfactant sodium cocoamphoacetate (CAP) and an outer layer of HA was electrosprayed in the same proportion as stated above. Eight nanofiber samples were fabricated, each varying in collector type, presence of LNG, and additional treatments with CAP. The mean diameter of samples ranged from 6.28 ± 0.27 pix to 5.38 ± 0.07 pix. The tensile strength, Young’s modulus and elongation at break were also determined. This study showed the relationship between formulation and processing parameters and the resulting fiber characteristics via image-based analysis and mechanical testing, highlighting the potential for precise control over nanofiber properties for tailoring nanofiber mats for delivery of Levonorgestrel in contraception.http://www.sciencedirect.com/science/article/pii/S2949822825002473Sodium Cocoamphoacetate (CAP)Polycaprolactone (PCL)Poly (lactic-co-glycolic acid) (PLGA)Hyaluronic Acid (HA)Levonorgestrel (LNG)Nanofibers |
| spellingShingle | Peace-OfonAbasi O. Bassey Bukola A. Oseni Deborah A. Ogundemuren Karamot O. Oyediran Evans N. Ekeji Dimitrios Tsamos Alkiviadis Tsamis Alexandros E. Tsouknidas Bryan C. Okwuba David A. Vorp Samson A. Adeosun Margaret O. Ilomuanya Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers Next Materials Sodium Cocoamphoacetate (CAP) Polycaprolactone (PCL) Poly (lactic-co-glycolic acid) (PLGA) Hyaluronic Acid (HA) Levonorgestrel (LNG) Nanofibers |
| title | Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers |
| title_full | Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers |
| title_fullStr | Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers |
| title_full_unstemmed | Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers |
| title_short | Assessment of microstructural architecture and mechanical properties of levonorgestrel loaded PCL/PLGA/HA nanofibers |
| title_sort | assessment of microstructural architecture and mechanical properties of levonorgestrel loaded pcl plga ha nanofibers |
| topic | Sodium Cocoamphoacetate (CAP) Polycaprolactone (PCL) Poly (lactic-co-glycolic acid) (PLGA) Hyaluronic Acid (HA) Levonorgestrel (LNG) Nanofibers |
| url | http://www.sciencedirect.com/science/article/pii/S2949822825002473 |
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