Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol
Introduction Hydrocephalus and myelomeningocele (MMC) place disproportionate burdens of disease on low-income and middle-income countries (LMICs). MMC-associated hydrocephalus and its sequelae result in a spectrum of severely devastating clinical manifestations, for which LMICs are disproportionatel...
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BMJ Publishing Group
2023-02-01
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| Series: | BMJ Open |
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| author | Seong Hoon Lee Anthony Figaji Abdullah Egiz Alvaro Yanez Touzet Conor S Gillespie Jay J Park Emily R Bligh Berjo Dongmo Takoutsing |
| author_facet | Seong Hoon Lee Anthony Figaji Abdullah Egiz Alvaro Yanez Touzet Conor S Gillespie Jay J Park Emily R Bligh Berjo Dongmo Takoutsing |
| author_sort | Seong Hoon Lee |
| collection | DOAJ |
| description | Introduction Hydrocephalus and myelomeningocele (MMC) place disproportionate burdens of disease on low-income and middle-income countries (LMICs). MMC-associated hydrocephalus and its sequelae result in a spectrum of severely devastating clinical manifestations, for which LMICs are disproportionately unprepared in terms of human, capital and technological resources. This study aims to review and compare the management and outcomes of infant MMC-associated hydrocephalus in LMICs and high-income countries.Methods and analysis This systematic review and meta-analysis will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The following databases will be searched without restrictions on language, publication date or country of origin: EMBASE, MEDLINE, The Cochrane Library, Global Index Medicus, African Journals Online and SciELO. All peer-reviewed studies of primary data reporting management and outcomes of infant MMC-associated hydrocephalus will be included. Where high-quality homogeneous studies exist, meta-analyses will be conducted to compare the management and outcomes of MMC-associated hydrocephalus across socioeconomic and geographical regions of the world. The primary outcome will be treatment failure of the first-line hydrocephalus treatment, which we defined operationally as the performance of a second intervention for the same reason as the first. Secondary outcomes include time to failure, rates of mortality and postoperative complications.Ethics and dissemination Ethical approval was not applicable because this study does not involve human participants. Dissemination strategies will include publication in a peer-reviewed journal, oral and poster presentations at conferences and an interactive web application to facilitate interaction with the findings and promote the discussion and sharing of findings on social media.PROSPERO registration number CRD42021285850. |
| format | Article |
| id | doaj-art-1554db46ee6245ffb2c042bf55826105 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-1554db46ee6245ffb2c042bf558261052025-08-20T02:46:32ZengBMJ Publishing GroupBMJ Open2044-60552023-02-0113210.1136/bmjopen-2022-066339Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocolSeong Hoon Lee0Anthony Figaji1Abdullah Egiz2Alvaro Yanez Touzet3Conor S Gillespie4Jay J Park5Emily R Bligh6Berjo Dongmo Takoutsing7Academic Critical Care & Neurosurgery, Aberdeen Royal Infirmary, Aberdeen, UKDivision of Paediatric Neuroscience (Neurosurgery), School of Child and Adolescent Health, University of Cape Town, Cape Town, South AfricaSchool of Medicine, University of Central Lancashire, Preston, UKSchool of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, University of Manchester, Manchester, UKNeurosurgery Division, Dept. Clinical Neurosciences, Cambridge University, Cambridge, UKEdinburgh Medical School, The University of Edinburgh, Edinburgh, UKSurgical Specialties, The Queen Elizabeth University Hospital, Glasgow, UKResearch Department, Association of Future African Neurosurgeons, Yaounde, CameroonIntroduction Hydrocephalus and myelomeningocele (MMC) place disproportionate burdens of disease on low-income and middle-income countries (LMICs). MMC-associated hydrocephalus and its sequelae result in a spectrum of severely devastating clinical manifestations, for which LMICs are disproportionately unprepared in terms of human, capital and technological resources. This study aims to review and compare the management and outcomes of infant MMC-associated hydrocephalus in LMICs and high-income countries.Methods and analysis This systematic review and meta-analysis will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The following databases will be searched without restrictions on language, publication date or country of origin: EMBASE, MEDLINE, The Cochrane Library, Global Index Medicus, African Journals Online and SciELO. All peer-reviewed studies of primary data reporting management and outcomes of infant MMC-associated hydrocephalus will be included. Where high-quality homogeneous studies exist, meta-analyses will be conducted to compare the management and outcomes of MMC-associated hydrocephalus across socioeconomic and geographical regions of the world. The primary outcome will be treatment failure of the first-line hydrocephalus treatment, which we defined operationally as the performance of a second intervention for the same reason as the first. Secondary outcomes include time to failure, rates of mortality and postoperative complications.Ethics and dissemination Ethical approval was not applicable because this study does not involve human participants. Dissemination strategies will include publication in a peer-reviewed journal, oral and poster presentations at conferences and an interactive web application to facilitate interaction with the findings and promote the discussion and sharing of findings on social media.PROSPERO registration number CRD42021285850.https://bmjopen.bmj.com/content/13/2/e066339.full |
| spellingShingle | Seong Hoon Lee Anthony Figaji Abdullah Egiz Alvaro Yanez Touzet Conor S Gillespie Jay J Park Emily R Bligh Berjo Dongmo Takoutsing Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol BMJ Open |
| title | Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol |
| title_full | Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol |
| title_fullStr | Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol |
| title_full_unstemmed | Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol |
| title_short | Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol |
| title_sort | management and outcomes of myelomeningocele associated hydrocephalus in low income and middle income countries a systematic review and meta analysis protocol |
| url | https://bmjopen.bmj.com/content/13/2/e066339.full |
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