Increased IFN responses drive myeloid cell activation in people living with HIV-1

Increased IFN responses drive myeloid cell activation in people living with HIV-1

Abstract People living with HIV and who initiated antiretroviral therapy (PLH) at the chronic stage of the infection are generally exposed to persistent inflammation. We here assessed the impact of the interferon (IFN)/JAK-STAT pathway on myeloid cells from PLH and the potential of a JAK1/2 inhibito...

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Main Authors: Léo Plaçais, Candie Joly, Vanessa d’Urbano, Annamaria Paolini, Marie Bitu, Christelliah Mouanga, Katia Bourdic, Delphine Desjardins, Delphine Bredel, Nathalie Chaput, Béatrice Jacquelin, Michaela Müller-Trütwin, Christine Bourgeois, Olivier Lambotte, Nicolas Noel
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-04613-0
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