Research progress on small extracellular vesicles in diabetic nephropathy
Virtually all cell types are capable of secreting small extracellular vesicles (sEV), which can be internalized by recipient cells, thereby serving as vehicles for intercellular communication. The cargoes of these vesicles, such as microRNAs, circular RNAs, proteins, and lipids, play significant rol...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1535249/full |
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| _version_ | 1850071065762463744 |
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| author | Bingqing Yu Bingqing Yu Lanfeng Wang Yiping Mao Yiping Mao Xinyi Hu Xinyi Hu Yukang Lu Yukang Lu Jiahui He Jiahui He Xiaoying Yuan Man Zhang Zhiping Chen Zhiping Chen Zhiping Chen |
| author_facet | Bingqing Yu Bingqing Yu Lanfeng Wang Yiping Mao Yiping Mao Xinyi Hu Xinyi Hu Yukang Lu Yukang Lu Jiahui He Jiahui He Xiaoying Yuan Man Zhang Zhiping Chen Zhiping Chen Zhiping Chen |
| author_sort | Bingqing Yu |
| collection | DOAJ |
| description | Virtually all cell types are capable of secreting small extracellular vesicles (sEV), which can be internalized by recipient cells, thereby serving as vehicles for intercellular communication. The cargoes of these vesicles, such as microRNAs, circular RNAs, proteins, and lipids, play significant roles in both normal cellular functions and the pathogenesis of various diseases. Diabetic Nephropathy (DN), a complication arising from diabetes, is expected to contribute to a 54% increase in the global diabetic population between 2015 and 2030, leading to substantial economic burdens on individuals and healthcare systems. sEVs, as promising biomarkers, demonstrate diverse mechanistic responses in different types of Diabetic Kidney Disease (DKD). They also hold advantages in the early prediction of renal damage. This article reviews the functional mechanisms of sEVs in DKD and their potential as therapeutic targets and biomarkers. |
| format | Article |
| id | doaj-art-154d171bcd2b4e9a85c5d5e23883fc7f |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-154d171bcd2b4e9a85c5d5e23883fc7f2025-08-20T02:47:24ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.15352491535249Research progress on small extracellular vesicles in diabetic nephropathyBingqing Yu0Bingqing Yu1Lanfeng Wang2Yiping Mao3Yiping Mao4Xinyi Hu5Xinyi Hu6Yukang Lu7Yukang Lu8Jiahui He9Jiahui He10Xiaoying Yuan11Man Zhang12Zhiping Chen13Zhiping Chen14Zhiping Chen15Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaFirst Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi, ChinaFirst Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaFirst Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi, ChinaFirst Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaVirtually all cell types are capable of secreting small extracellular vesicles (sEV), which can be internalized by recipient cells, thereby serving as vehicles for intercellular communication. The cargoes of these vesicles, such as microRNAs, circular RNAs, proteins, and lipids, play significant roles in both normal cellular functions and the pathogenesis of various diseases. Diabetic Nephropathy (DN), a complication arising from diabetes, is expected to contribute to a 54% increase in the global diabetic population between 2015 and 2030, leading to substantial economic burdens on individuals and healthcare systems. sEVs, as promising biomarkers, demonstrate diverse mechanistic responses in different types of Diabetic Kidney Disease (DKD). They also hold advantages in the early prediction of renal damage. This article reviews the functional mechanisms of sEVs in DKD and their potential as therapeutic targets and biomarkers.https://www.frontiersin.org/articles/10.3389/fcell.2025.1535249/fulldiabetic nephropathysmall extracellular vesiclestherapybiomarkersprogress |
| spellingShingle | Bingqing Yu Bingqing Yu Lanfeng Wang Yiping Mao Yiping Mao Xinyi Hu Xinyi Hu Yukang Lu Yukang Lu Jiahui He Jiahui He Xiaoying Yuan Man Zhang Zhiping Chen Zhiping Chen Zhiping Chen Research progress on small extracellular vesicles in diabetic nephropathy Frontiers in Cell and Developmental Biology diabetic nephropathy small extracellular vesicles therapy biomarkers progress |
| title | Research progress on small extracellular vesicles in diabetic nephropathy |
| title_full | Research progress on small extracellular vesicles in diabetic nephropathy |
| title_fullStr | Research progress on small extracellular vesicles in diabetic nephropathy |
| title_full_unstemmed | Research progress on small extracellular vesicles in diabetic nephropathy |
| title_short | Research progress on small extracellular vesicles in diabetic nephropathy |
| title_sort | research progress on small extracellular vesicles in diabetic nephropathy |
| topic | diabetic nephropathy small extracellular vesicles therapy biomarkers progress |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1535249/full |
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