Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms
Robustness is the key feature of biological networks that enables living organisms to keep their homeostatic state and to survive against external and internal perturbations. Variations in environmental conditions or nutrients and intracellular changes such as genetic mutations have the potential to...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/615697 |
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| _version_ | 1849308507883438080 |
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| author | Sayed-Amir Marashi Hawa Kouhestani Majid Mahdavi |
| author_facet | Sayed-Amir Marashi Hawa Kouhestani Majid Mahdavi |
| author_sort | Sayed-Amir Marashi |
| collection | DOAJ |
| description | Robustness is the key feature of biological networks that enables living organisms to keep their homeostatic state and to survive against external and internal perturbations. Variations in environmental conditions or nutrients and intracellular changes such as genetic mutations have the potential to change stability and efficiency of an organism. Structural robustness helps biological systems to choose alternative routes of adaptation to varying conditions. In this study, in order to estimate the structural robustness in metabolic networks we presented a novel flux balance-based approach inspired by bond percolation theory. Fourteen in silico metabolic models were studied in this work in order to examine the possible relationship between the lifestyle of organisms and their metabolic robustness. The results of this study confirm that in organisms which are highly adapted to their environment robustness to mutations may decrease compared to other organisms. |
| format | Article |
| id | doaj-art-154c1b4f68dc495b877ff6c95f2eac47 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-154c1b4f68dc495b877ff6c95f2eac472025-08-20T03:54:25ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/615697615697Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of OrganismsSayed-Amir Marashi0Hawa Kouhestani1Majid Mahdavi2Department of Biotechnology, College of Science, University of Tehran, Tehran 1417614411, IranDepartment of Biology, Faculty of Natural Science, University of Tabriz, Tabriz 5166616471, IranDepartment of Biology, Faculty of Natural Science, University of Tabriz, Tabriz 5166616471, IranRobustness is the key feature of biological networks that enables living organisms to keep their homeostatic state and to survive against external and internal perturbations. Variations in environmental conditions or nutrients and intracellular changes such as genetic mutations have the potential to change stability and efficiency of an organism. Structural robustness helps biological systems to choose alternative routes of adaptation to varying conditions. In this study, in order to estimate the structural robustness in metabolic networks we presented a novel flux balance-based approach inspired by bond percolation theory. Fourteen in silico metabolic models were studied in this work in order to examine the possible relationship between the lifestyle of organisms and their metabolic robustness. The results of this study confirm that in organisms which are highly adapted to their environment robustness to mutations may decrease compared to other organisms.http://dx.doi.org/10.1155/2013/615697 |
| spellingShingle | Sayed-Amir Marashi Hawa Kouhestani Majid Mahdavi Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms The Scientific World Journal |
| title | Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms |
| title_full | Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms |
| title_fullStr | Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms |
| title_full_unstemmed | Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms |
| title_short | Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms |
| title_sort | studying the relationship between robustness against mutations in metabolic networks and lifestyle of organisms |
| url | http://dx.doi.org/10.1155/2013/615697 |
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