Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men
Background. Irisin is a myokine that has a beneficial effect on obesity and glucose metabolism by increasing energy expenditure. This study aims to investigate the effect of long-term moderate physical exercise on irisin levels and its correlations with body mass index (BMI), waist circumferences (W...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2020/1897027 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308507621294080 |
|---|---|
| author | Farah A. Rashid Hamid Jaddoa Abbas Naser Ali Naser Hana'a Addai Ali |
| author_facet | Farah A. Rashid Hamid Jaddoa Abbas Naser Ali Naser Hana'a Addai Ali |
| author_sort | Farah A. Rashid |
| collection | DOAJ |
| description | Background. Irisin is a myokine that has a beneficial effect on obesity and glucose metabolism by increasing energy expenditure. This study aims to investigate the effect of long-term moderate physical exercise on irisin levels and its correlations with body mass index (BMI), waist circumferences (WC), and metabolic parameters in normal weight and obese males. Material and method. A follow-up case-control study of sixty male participants, comprised of thirty normal weight and thirty obese, who had undergone supervised long-term moderate physical exercises for six months. Serum irisin levels, fasting blood glucose, serum insulin, homeostatic model assessment of the insulin resistance index (HOMA-IR), and β-cell function (HOMA-B2) were assessed. Results. Long-term moderate exercise induced elevation of the irisin level significantly (P<0.0001) with significant reduction of the BMI, WC, fasting blood glucose, insulin, HOMA-IR, and HOMA-B2 levels (P<0.0001) in comparison between obese and normal weight groups. There are significant differences for each parameter in each obese and normal weight group before and after physical exercise with exception of the BMI and WC in the normal group. Significant negative correlations were shown between irisin and blood glucose and insulin and HOMA-IR levels in the obese group and normal weight group. Conclusion. Irisin improves glucose homeostasis after long-term moderate physical exercises, suggesting that irisin could have regulatory effect on glucose, insulin resistance, and obesity and it could be used as a potential therapy for obesity and insulin resistance. |
| format | Article |
| id | doaj-art-154b91c690854bdba4d395dca8985a23 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-154b91c690854bdba4d395dca8985a232025-08-20T03:54:25ZengWileyThe Scientific World Journal2356-61401537-744X2020-01-01202010.1155/2020/18970271897027Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese MenFarah A. Rashid0Hamid Jaddoa Abbas1Naser Ali Naser2Hana'a Addai Ali3Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, IraqAlzahraa Medical College, Basrah, IraqAl-Faiha’a Teaching Hospital, Basrah, IraqDepartment of Chemistry, College of Science, University of Kufa, Najaf, IraqBackground. Irisin is a myokine that has a beneficial effect on obesity and glucose metabolism by increasing energy expenditure. This study aims to investigate the effect of long-term moderate physical exercise on irisin levels and its correlations with body mass index (BMI), waist circumferences (WC), and metabolic parameters in normal weight and obese males. Material and method. A follow-up case-control study of sixty male participants, comprised of thirty normal weight and thirty obese, who had undergone supervised long-term moderate physical exercises for six months. Serum irisin levels, fasting blood glucose, serum insulin, homeostatic model assessment of the insulin resistance index (HOMA-IR), and β-cell function (HOMA-B2) were assessed. Results. Long-term moderate exercise induced elevation of the irisin level significantly (P<0.0001) with significant reduction of the BMI, WC, fasting blood glucose, insulin, HOMA-IR, and HOMA-B2 levels (P<0.0001) in comparison between obese and normal weight groups. There are significant differences for each parameter in each obese and normal weight group before and after physical exercise with exception of the BMI and WC in the normal group. Significant negative correlations were shown between irisin and blood glucose and insulin and HOMA-IR levels in the obese group and normal weight group. Conclusion. Irisin improves glucose homeostasis after long-term moderate physical exercises, suggesting that irisin could have regulatory effect on glucose, insulin resistance, and obesity and it could be used as a potential therapy for obesity and insulin resistance.http://dx.doi.org/10.1155/2020/1897027 |
| spellingShingle | Farah A. Rashid Hamid Jaddoa Abbas Naser Ali Naser Hana'a Addai Ali Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men The Scientific World Journal |
| title | Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men |
| title_full | Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men |
| title_fullStr | Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men |
| title_full_unstemmed | Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men |
| title_short | Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men |
| title_sort | effect of long term moderate physical exercise on irisin between normal weight and obese men |
| url | http://dx.doi.org/10.1155/2020/1897027 |
| work_keys_str_mv | AT faraharashid effectoflongtermmoderatephysicalexerciseonirisinbetweennormalweightandobesemen AT hamidjaddoaabbas effectoflongtermmoderatephysicalexerciseonirisinbetweennormalweightandobesemen AT naseralinaser effectoflongtermmoderatephysicalexerciseonirisinbetweennormalweightandobesemen AT hanaaaddaiali effectoflongtermmoderatephysicalexerciseonirisinbetweennormalweightandobesemen |