Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line
The study explores the green synthesis and characterization of silver nanoparticles using Syzygium malaccense (L.) Merr. & L. M. Perry leaf extract (SM-AgNPs). UV-Visible spectroscopy confirmed the reduction of silver ions, showing an absorption peak at 406 nm. X-ray Diffraction (XRD) analysis r...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Green Chemistry Letters and Reviews |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2025.2456624 |
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| author | Santosh Mallikarjun Bhavi Bothe Thokchom Sapam Riches Singh Sukesh Kumar Bajire Rajesh P. Shastry B. S. Srinath Shivanand S. Bhat Kotresha Dupadahalli Chandramohan Govindasamy Swati Ravi Chalekar B. P. Harini Ramesh Babu Yarajarla |
| author_facet | Santosh Mallikarjun Bhavi Bothe Thokchom Sapam Riches Singh Sukesh Kumar Bajire Rajesh P. Shastry B. S. Srinath Shivanand S. Bhat Kotresha Dupadahalli Chandramohan Govindasamy Swati Ravi Chalekar B. P. Harini Ramesh Babu Yarajarla |
| author_sort | Santosh Mallikarjun Bhavi |
| collection | DOAJ |
| description | The study explores the green synthesis and characterization of silver nanoparticles using Syzygium malaccense (L.) Merr. & L. M. Perry leaf extract (SM-AgNPs). UV-Visible spectroscopy confirmed the reduction of silver ions, showing an absorption peak at 406 nm. X-ray Diffraction (XRD) analysis revealed a face centered cubic structure with an average particle size of 23.55 nm. Dynamic Light Scattering (DLS) and zeta potential analyses indicated a mean size of 40.1 nm and a surface charge of −40.1 mV. FTIR spectroscopy identified functional groups involved in nanoparticle stabilization, while Energy Dispersive X-ray (EDX) analysis confirmed silver content. Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM) provided detailed insights into particle morphology. Anticancer assays showed dose-dependent cytotoxicity against A549 cancer cells (LC50: 7.62 μg mL−1) with minimal effects on L-132 normal cells (LC50: 73.55 μg mL−1), highlighting selectivity. Additionally, SM-AgNPs increased Caenorhabditis elegans survival and reduced paralysis under pathogenic bacterial exposure. This study demonstrates the potential of SM-AgNPs in biomedical applications, emphasizing selective anticancer activity and antimicrobial effects in vivo. |
| format | Article |
| id | doaj-art-15433e558ace4bbfaa2fd3944d248558 |
| institution | Kabale University |
| issn | 1751-8253 1751-7192 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj-art-15433e558ace4bbfaa2fd3944d2485582025-01-31T04:39:21ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922025-12-0118110.1080/17518253.2025.2456624Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell lineSantosh Mallikarjun Bhavi0Bothe Thokchom1Sapam Riches Singh2Sukesh Kumar Bajire3Rajesh P. Shastry4B. S. Srinath5Shivanand S. Bhat6Kotresha Dupadahalli7Chandramohan Govindasamy8Swati Ravi Chalekar9B. P. Harini10Ramesh Babu Yarajarla11Drosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, IndiaDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, IndiaDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, IndiaDivision of Microbiology and Biotechnology, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, IndiaDivision of Microbiology and Biotechnology, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, IndiaDepartment of Microbiology and Biotechnology, Bangalore University, Bangalore, IndiaDepartment of Botany, Smt. Indira Gandhi Government First Grade Women’s College, Sagar, IndiaDepartment of Studies in Botany, Davangere University, Tholahunase, IndiaDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, IndiaDepartment of Zoology, Bangalore University, Bangalore, IndiaDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, IndiaThe study explores the green synthesis and characterization of silver nanoparticles using Syzygium malaccense (L.) Merr. & L. M. Perry leaf extract (SM-AgNPs). UV-Visible spectroscopy confirmed the reduction of silver ions, showing an absorption peak at 406 nm. X-ray Diffraction (XRD) analysis revealed a face centered cubic structure with an average particle size of 23.55 nm. Dynamic Light Scattering (DLS) and zeta potential analyses indicated a mean size of 40.1 nm and a surface charge of −40.1 mV. FTIR spectroscopy identified functional groups involved in nanoparticle stabilization, while Energy Dispersive X-ray (EDX) analysis confirmed silver content. Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM) provided detailed insights into particle morphology. Anticancer assays showed dose-dependent cytotoxicity against A549 cancer cells (LC50: 7.62 μg mL−1) with minimal effects on L-132 normal cells (LC50: 73.55 μg mL−1), highlighting selectivity. Additionally, SM-AgNPs increased Caenorhabditis elegans survival and reduced paralysis under pathogenic bacterial exposure. This study demonstrates the potential of SM-AgNPs in biomedical applications, emphasizing selective anticancer activity and antimicrobial effects in vivo.https://www.tandfonline.com/doi/10.1080/17518253.2025.2456624Green synthesissilver nanoparticlescharacterizationSyzygium malaccenseC. elegansanticancer |
| spellingShingle | Santosh Mallikarjun Bhavi Bothe Thokchom Sapam Riches Singh Sukesh Kumar Bajire Rajesh P. Shastry B. S. Srinath Shivanand S. Bhat Kotresha Dupadahalli Chandramohan Govindasamy Swati Ravi Chalekar B. P. Harini Ramesh Babu Yarajarla Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line Green Chemistry Letters and Reviews Green synthesis silver nanoparticles characterization Syzygium malaccense C. elegans anticancer |
| title | Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line |
| title_full | Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line |
| title_fullStr | Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line |
| title_full_unstemmed | Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line |
| title_short | Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line |
| title_sort | syzygium malaccense leaf extract mediated silver nanoparticles synthesis characterization and biomedical evaluation in caenorhabditis elegans and lung cancer cell line |
| topic | Green synthesis silver nanoparticles characterization Syzygium malaccense C. elegans anticancer |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2025.2456624 |
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