The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study
Abstract Background Several studies pointed out the importance of genetic risk factors such as parental consanguinity (PC) and familial multiple sclerosis (FMS) in the risk of MS. This study aimed to investigate the PC and FMS among people with MS (pwMS) in Isfahan, Iran. Methods This case–control s...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-10-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-024-02094-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850182495527501824 |
|---|---|
| author | Saeed Vaheb Mohammad Yazdan Panah Alireza Afshari-Safavi Elham Moases Ghaffary Aysa Shaygannejad Vahid Shaygannejad Omid Mirmosayyeb |
| author_facet | Saeed Vaheb Mohammad Yazdan Panah Alireza Afshari-Safavi Elham Moases Ghaffary Aysa Shaygannejad Vahid Shaygannejad Omid Mirmosayyeb |
| author_sort | Saeed Vaheb |
| collection | DOAJ |
| description | Abstract Background Several studies pointed out the importance of genetic risk factors such as parental consanguinity (PC) and familial multiple sclerosis (FMS) in the risk of MS. This study aimed to investigate the PC and FMS among people with MS (pwMS) in Isfahan, Iran. Methods This case–control study was conducted on pwMS from the MS clinic of Kashani Hospital, Isfahan, Iran, in October 2023. A group of healthy controls (HC) were also recruited. Data on demographic and clinical characteristics and history of PC and FMS were collected from participants. The relationships between PC, FMS, and developing MS were assessed using multinomial logistic regression analysis. The odds ratio (OR) with a 95% confidence interval (CI) was computed. Results A total number of 4264 pwMS and 400 HCs were included. The prevalence of PC and FMS among pwMS were 29.3% and 24%, respectively. Multinomial logistic regression adjusted for age and sex indicated that the odds of developing MS were significantly associated with a history of PC (OR = 3.03, 95% CI 2.23 to 4.13, p < 0.001) and FMS (OR = 5.42, 95% CI 3.51 to 8.38, p < 0.001). Conclusion PC and FMS can increase the risk of developing MS. They should be considered along with other risk factors for developing MS. A comprehensive conclusion requires further research. |
| format | Article |
| id | doaj-art-153f261fc6df4427ad3baf941a2b2dcf |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-153f261fc6df4427ad3baf941a2b2dcf2025-08-20T02:17:37ZengBMCEuropean Journal of Medical Research2047-783X2024-10-0129111110.1186/s40001-024-02094-xThe role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control studySaeed Vaheb0Mohammad Yazdan Panah1Alireza Afshari-Safavi2Elham Moases Ghaffary3Aysa Shaygannejad4Vahid Shaygannejad5Omid Mirmosayyeb6Isfahan Neurosciences Research Center, Isfahan University of Medical SciencesStudents Research Committee, Shahrekord University of Medical SciencesDepartment of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical SciencesIsfahan Neurosciences Research Center, Isfahan University of Medical SciencesIsfahan Neurosciences Research Center, Isfahan University of Medical SciencesIsfahan Neurosciences Research Center, Isfahan University of Medical SciencesIsfahan Neurosciences Research Center, Isfahan University of Medical SciencesAbstract Background Several studies pointed out the importance of genetic risk factors such as parental consanguinity (PC) and familial multiple sclerosis (FMS) in the risk of MS. This study aimed to investigate the PC and FMS among people with MS (pwMS) in Isfahan, Iran. Methods This case–control study was conducted on pwMS from the MS clinic of Kashani Hospital, Isfahan, Iran, in October 2023. A group of healthy controls (HC) were also recruited. Data on demographic and clinical characteristics and history of PC and FMS were collected from participants. The relationships between PC, FMS, and developing MS were assessed using multinomial logistic regression analysis. The odds ratio (OR) with a 95% confidence interval (CI) was computed. Results A total number of 4264 pwMS and 400 HCs were included. The prevalence of PC and FMS among pwMS were 29.3% and 24%, respectively. Multinomial logistic regression adjusted for age and sex indicated that the odds of developing MS were significantly associated with a history of PC (OR = 3.03, 95% CI 2.23 to 4.13, p < 0.001) and FMS (OR = 5.42, 95% CI 3.51 to 8.38, p < 0.001). Conclusion PC and FMS can increase the risk of developing MS. They should be considered along with other risk factors for developing MS. A comprehensive conclusion requires further research.https://doi.org/10.1186/s40001-024-02094-xMultiple sclerosisParental consanguinityFamilial multiple sclerosis |
| spellingShingle | Saeed Vaheb Mohammad Yazdan Panah Alireza Afshari-Safavi Elham Moases Ghaffary Aysa Shaygannejad Vahid Shaygannejad Omid Mirmosayyeb The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study European Journal of Medical Research Multiple sclerosis Parental consanguinity Familial multiple sclerosis |
| title | The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study |
| title_full | The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study |
| title_fullStr | The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study |
| title_full_unstemmed | The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study |
| title_short | The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case–control study |
| title_sort | role of parental consanguinity and familial aggregation in development of multiple sclerosis a case control study |
| topic | Multiple sclerosis Parental consanguinity Familial multiple sclerosis |
| url | https://doi.org/10.1186/s40001-024-02094-x |
| work_keys_str_mv | AT saeedvaheb theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT mohammadyazdanpanah theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT alirezaafsharisafavi theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT elhammoasesghaffary theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT aysashaygannejad theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT vahidshaygannejad theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT omidmirmosayyeb theroleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT saeedvaheb roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT mohammadyazdanpanah roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT alirezaafsharisafavi roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT elhammoasesghaffary roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT aysashaygannejad roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT vahidshaygannejad roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy AT omidmirmosayyeb roleofparentalconsanguinityandfamilialaggregationindevelopmentofmultiplesclerosisacasecontrolstudy |