Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae
The Enterobacteriaceae family are the most common pathogens associated with hospital and community acquired infections worldwide. These bacteria are treated with broad spectrum antibiotics especially 3rd generation cephalosporins. Over the period of time due widespread and rigorous use of these med...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2022-10-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1021 |
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| author | Rida Sohail Yasmeen Taj Luqman Satti Shaista Bakhat |
| author_facet | Rida Sohail Yasmeen Taj Luqman Satti Shaista Bakhat |
| author_sort | Rida Sohail |
| collection | DOAJ |
| description |
The Enterobacteriaceae family are the most common pathogens associated with hospital and community acquired infections
worldwide. These bacteria are treated with broad spectrum antibiotics especially 3rd generation cephalosporins. Over the
period of time due widespread and rigorous use of these medications, Enterobacteriaceae has developed antibiotic resistance
(AMR). Among all, the most compelling antibiotic resistance mechanism is production of -lactamases enzymes by this
microorganism. Over the course of time -lactamase has evolved more than 1300 distinct enzymes. Amongst these most
deleterious is extended spectrum beta lactamases (ESBL). ESBL producing Enterbacteriacaeae are responsible for a
high number of deaths worldwide. These enzymes are considered challenging as they are difficult to be identified in the
laboratory wShich cause delay in diagnosis and administration of appropriate antimicrobial therapy. The coexistence of
ESBL with other antibiotic resistance gene is another therapeutic challenge rendering empirical antibiotic treatment
ineffective.
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| format | Article |
| id | doaj-art-153e5a0a5a7947e9be5d4f575a1de7ea |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-153e5a0a5a7947e9be5d4f575a1de7ea2025-08-20T03:13:13ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822022-10-01120410.51985/JBUMDC202230Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in EnterobacteriaceaeRida SohailYasmeen TajLuqman SattiShaista Bakhat The Enterobacteriaceae family are the most common pathogens associated with hospital and community acquired infections worldwide. These bacteria are treated with broad spectrum antibiotics especially 3rd generation cephalosporins. Over the period of time due widespread and rigorous use of these medications, Enterobacteriaceae has developed antibiotic resistance (AMR). Among all, the most compelling antibiotic resistance mechanism is production of -lactamases enzymes by this microorganism. Over the course of time -lactamase has evolved more than 1300 distinct enzymes. Amongst these most deleterious is extended spectrum beta lactamases (ESBL). ESBL producing Enterbacteriacaeae are responsible for a high number of deaths worldwide. These enzymes are considered challenging as they are difficult to be identified in the laboratory wShich cause delay in diagnosis and administration of appropriate antimicrobial therapy. The coexistence of ESBL with other antibiotic resistance gene is another therapeutic challenge rendering empirical antibiotic treatment ineffective. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1021Enterbacteriacaeae, AMR, ESBL, CTX-M |
| spellingShingle | Rida Sohail Yasmeen Taj Luqman Satti Shaista Bakhat Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae Journal of Bahria University Medical and Dental College Enterbacteriacaeae, AMR, ESBL, CTX-M |
| title | Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae |
| title_full | Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae |
| title_fullStr | Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae |
| title_full_unstemmed | Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae |
| title_short | Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae |
| title_sort | drug resistance due to elaboration of beta lactamases and the role of ctx m in enterobacteriaceae |
| topic | Enterbacteriacaeae, AMR, ESBL, CTX-M |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1021 |
| work_keys_str_mv | AT ridasohail drugresistanceduetoelaborationofbetalactamasesandtheroleofctxminenterobacteriaceae AT yasmeentaj drugresistanceduetoelaborationofbetalactamasesandtheroleofctxminenterobacteriaceae AT luqmansatti drugresistanceduetoelaborationofbetalactamasesandtheroleofctxminenterobacteriaceae AT shaistabakhat drugresistanceduetoelaborationofbetalactamasesandtheroleofctxminenterobacteriaceae |