Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward
ObjectiveTo investigate a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) in a geriatric emergency ward, and to provide references for the prevention and control of multidrug-resistant bacteria in a hospital in Shanghai.MethodsOn-site epid...
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| Format: | Article |
| Language: | zho |
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Shanghai Preventive Medicine Association
2025-04-01
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| Series: | Shanghai yufang yixue |
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| Online Access: | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24819 |
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| author | CHEN Yue QIAN Ziyu ZHANG Jinghao LIU Zhiyong WANG Kaiyue YU Yayan DAI Xujuan JIA Minglei CHEN Yuehuo |
| author_facet | CHEN Yue QIAN Ziyu ZHANG Jinghao LIU Zhiyong WANG Kaiyue YU Yayan DAI Xujuan JIA Minglei CHEN Yuehuo |
| author_sort | CHEN Yue |
| collection | DOAJ |
| description | ObjectiveTo investigate a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) in a geriatric emergency ward, and to provide references for the prevention and control of multidrug-resistant bacteria in a hospital in Shanghai.MethodsOn-site epidemiological investigation, combined with environmental hygiene monitoring and pulsed field gel electrophoresis (PFGE) molecular typing method, were adopted to investigate a suspected outbreak of CRKP infection in the geriatric emergency ward of a hospital from October to November 2022, aiming at finding out factors caused the outbreak before taking corresponding control measures.ResultsA total of 3 cases of healthcare-associated CRKP infection were identified, of which 2 cases were homologous to a previous case of community-associated CRKP infection. What’s more, the 2 cases lived in the same ward with the latter and with adjacent beds, but the third case was non-homologous to the community-associated infection case. A total of 46 samples were collected from the environmental surfaces and the hands of healthcare workers, of which 7 samples tested positive for CRKP and were identical to the strains from the 2 healthcare-associated infection cases and the 1 community-associated infection case, originating from the bedrails, bedside tables, surface of non-invasive ventilator, bed curtains and panels of monitoring equipment, with a detection rate of 15.22%. But none of the 11 samples from the hands of healthcare workers tested positive for CRKP. The outbreak was effectively controlled after taking specific prevention and control measures such as strengthening personnel management, intensifying environmental cleaning and disinfection and strictly enforcing hand hygiene among healthcare workers. Subsequently, no similar new cases were reported during the 14-day follow-up period.ConclusionIncomplete environmental cleaning and disinfection, as well as inadequate enforcement of hand hygiene among heatheare workers may have contributed to the suspected outbreak of CRKP in the geriatric emergency ward. Early warning and timely investigation of suspected outbreaks of multidrug-resistant bacteria are crucial for preventing and controlling such outbreaks in hospitals. |
| format | Article |
| id | doaj-art-153bf99b5a2e4658b42aaba02de25947 |
| institution | Kabale University |
| issn | 1004-9231 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj-art-153bf99b5a2e4658b42aaba02de259472025-08-20T03:31:14ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312025-04-0137430130510.19428/j.cnki.sjpm.2025.248191004-9231（2025）04-0301-05Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency wardCHEN Yue0QIAN Ziyu1ZHANG Jinghao2LIU Zhiyong3WANG Kaiyue4YU Yayan5DAI Xujuan6JIA Minglei7CHEN Yuehuo8Department of Healthcare-associated Infection Management, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaXuhui District Center for Disease Control and Prevention, Shanghai 200030, ChinaDepartment of Clinical Laboratory, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaXuhui District Center for Disease Control and Prevention, Shanghai 200030, ChinaXuhui District Center for Disease Control and Prevention, Shanghai 200030, ChinaDepartment of Healthcare-associated Infection Management, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaDepartment of Healthcare-associated Infection Management, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaDepartment of Healthcare-associated Infection Management, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaDepartment of Healthcare-associated Infection Management, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaObjectiveTo investigate a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) in a geriatric emergency ward, and to provide references for the prevention and control of multidrug-resistant bacteria in a hospital in Shanghai.MethodsOn-site epidemiological investigation, combined with environmental hygiene monitoring and pulsed field gel electrophoresis (PFGE) molecular typing method, were adopted to investigate a suspected outbreak of CRKP infection in the geriatric emergency ward of a hospital from October to November 2022, aiming at finding out factors caused the outbreak before taking corresponding control measures.ResultsA total of 3 cases of healthcare-associated CRKP infection were identified, of which 2 cases were homologous to a previous case of community-associated CRKP infection. What’s more, the 2 cases lived in the same ward with the latter and with adjacent beds, but the third case was non-homologous to the community-associated infection case. A total of 46 samples were collected from the environmental surfaces and the hands of healthcare workers, of which 7 samples tested positive for CRKP and were identical to the strains from the 2 healthcare-associated infection cases and the 1 community-associated infection case, originating from the bedrails, bedside tables, surface of non-invasive ventilator, bed curtains and panels of monitoring equipment, with a detection rate of 15.22%. But none of the 11 samples from the hands of healthcare workers tested positive for CRKP. The outbreak was effectively controlled after taking specific prevention and control measures such as strengthening personnel management, intensifying environmental cleaning and disinfection and strictly enforcing hand hygiene among healthcare workers. Subsequently, no similar new cases were reported during the 14-day follow-up period.ConclusionIncomplete environmental cleaning and disinfection, as well as inadequate enforcement of hand hygiene among heatheare workers may have contributed to the suspected outbreak of CRKP in the geriatric emergency ward. Early warning and timely investigation of suspected outbreaks of multidrug-resistant bacteria are crucial for preventing and controlling such outbreaks in hospitals.http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24819carbapenem-resistant klebsiella pneumoniaesuspected outbreak of healthcare-associated infectiongeriatric emergency wardpulsed field gel electrophoresisepidemiological investigation |
| spellingShingle | CHEN Yue QIAN Ziyu ZHANG Jinghao LIU Zhiyong WANG Kaiyue YU Yayan DAI Xujuan JIA Minglei CHEN Yuehuo Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward Shanghai yufang yixue carbapenem-resistant klebsiella pneumoniae suspected outbreak of healthcare-associated infection geriatric emergency ward pulsed field gel electrophoresis epidemiological investigation |
| title | Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward |
| title_full | Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward |
| title_fullStr | Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward |
| title_full_unstemmed | Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward |
| title_short | Epidemiological investigation of a suspected outbreak of healthcare-associated infection with carbapenem-resistant Klebsiella pneumoniae in a geriatric emergency ward |
| title_sort | epidemiological investigation of a suspected outbreak of healthcare associated infection with carbapenem resistant klebsiella pneumoniae in a geriatric emergency ward |
| topic | carbapenem-resistant klebsiella pneumoniae suspected outbreak of healthcare-associated infection geriatric emergency ward pulsed field gel electrophoresis epidemiological investigation |
| url | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24819 |
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