SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas

SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas

Abstract Chordomas are rare, aggressive tumors of the axial skeleton with limited treatment options. Genetic alterations in SMARCB1, a tumor suppressor gene, have been implicated in poorly differentiated chordomas, but their role in typical and chondroid subtypes remains unclear. This study examined...

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Bibliographic Details
Main Authors: Weihai Liu, Moksada Regmi, Shikun Liu, Ying Xiong, Yuwei Dai, Yingjie Wang, Jun Yang, Chenlong Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Chordoma
SMARCB1
Tumor suppressor gene
Chromatin remodeling
Prognosis
Online Access:https://doi.org/10.1038/s41598-025-04508-0
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