Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves

Background: Vitis vinifera is universally appreciated herb (especially fruit) for their delicacy, nutrition and conventional as functional food. In the present study, we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats. Material and...

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Main Authors: Sushma Devi, Randhir Singh
Format: Article
Language:English
Published: Tsinghua University Press 2017-09-01
Series:Food Science and Human Wellness
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213453016301161
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author Sushma Devi
Randhir Singh
author_facet Sushma Devi
Randhir Singh
author_sort Sushma Devi
collection DOAJ
description Background: Vitis vinifera is universally appreciated herb (especially fruit) for their delicacy, nutrition and conventional as functional food. In the present study, we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats. Material and methods: Qualitative and quantitative phytochemical screening of vitis vinifera methanolic extract (VVME) and vitis vinifera aqueous extract aqueous (VVAE) extract was carried out to identify the phytoconstituents. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. During the experimental periods parameters like lipid profile, liver function test, atherogenic index and histopathological studies were analysed. Results: Total tannins, total flavonoids and total phenolic contents were found in major amount in VVME. The lipid levels were significantly attenuated by different doses of VVME and VVAE. Moreover, VVME was found more effective than VVAE and histopathological results confirmed the effectiveness of VVME. Conclusion: It can be concluded that anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of active phytoconstituents and its antioxidant efficacy.
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spelling doaj-art-1533022a641a44e08c5dbfdcfcbf77e22025-02-03T05:38:39ZengTsinghua University PressFood Science and Human Wellness2213-45302017-09-016313113610.1016/j.fshw.2017.07.002Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leavesSushma DeviRandhir SinghBackground: Vitis vinifera is universally appreciated herb (especially fruit) for their delicacy, nutrition and conventional as functional food. In the present study, we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats. Material and methods: Qualitative and quantitative phytochemical screening of vitis vinifera methanolic extract (VVME) and vitis vinifera aqueous extract aqueous (VVAE) extract was carried out to identify the phytoconstituents. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. During the experimental periods parameters like lipid profile, liver function test, atherogenic index and histopathological studies were analysed. Results: Total tannins, total flavonoids and total phenolic contents were found in major amount in VVME. The lipid levels were significantly attenuated by different doses of VVME and VVAE. Moreover, VVME was found more effective than VVAE and histopathological results confirmed the effectiveness of VVME. Conclusion: It can be concluded that anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of active phytoconstituents and its antioxidant efficacy.http://www.sciencedirect.com/science/article/pii/S2213453016301161Vitis viniferaHypercholesterolemiaCholesterol dietTotal phenolic content
spellingShingle Sushma Devi
Randhir Singh
Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
Food Science and Human Wellness
Vitis vinifera
Hypercholesterolemia
Cholesterol diet
Total phenolic content
title Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
title_full Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
title_fullStr Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
title_full_unstemmed Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
title_short Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
title_sort evaluation of antioxidant and anti hypercholesterolemic potential of vitis vinifera leaves
topic Vitis vinifera
Hypercholesterolemia
Cholesterol diet
Total phenolic content
url http://www.sciencedirect.com/science/article/pii/S2213453016301161
work_keys_str_mv AT sushmadevi evaluationofantioxidantandantihypercholesterolemicpotentialofvitisviniferaleaves
AT randhirsingh evaluationofantioxidantandantihypercholesterolemicpotentialofvitisviniferaleaves