Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves
Background: Vitis vinifera is universally appreciated herb (especially fruit) for their delicacy, nutrition and conventional as functional food. In the present study, we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats. Material and...
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Tsinghua University Press
2017-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016301161 |
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| author | Sushma Devi Randhir Singh |
| author_facet | Sushma Devi Randhir Singh |
| author_sort | Sushma Devi |
| collection | DOAJ |
| description | Background: Vitis vinifera is universally appreciated herb (especially fruit) for their delicacy, nutrition and conventional as functional food. In the present study, we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats.
Material and methods: Qualitative and quantitative phytochemical screening of vitis vinifera methanolic extract (VVME) and vitis vinifera aqueous extract aqueous (VVAE) extract was carried out to identify the phytoconstituents. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. During the experimental periods parameters like lipid profile, liver function test, atherogenic index and histopathological studies were analysed.
Results: Total tannins, total flavonoids and total phenolic contents were found in major amount in VVME. The lipid levels were significantly attenuated by different doses of VVME and VVAE. Moreover, VVME was found more effective than VVAE and histopathological results confirmed the effectiveness of VVME.
Conclusion: It can be concluded that anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of active phytoconstituents and its antioxidant efficacy. |
| format | Article |
| id | doaj-art-1533022a641a44e08c5dbfdcfcbf77e2 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-1533022a641a44e08c5dbfdcfcbf77e22025-02-03T05:38:39ZengTsinghua University PressFood Science and Human Wellness2213-45302017-09-016313113610.1016/j.fshw.2017.07.002Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leavesSushma DeviRandhir SinghBackground: Vitis vinifera is universally appreciated herb (especially fruit) for their delicacy, nutrition and conventional as functional food. In the present study, we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats. Material and methods: Qualitative and quantitative phytochemical screening of vitis vinifera methanolic extract (VVME) and vitis vinifera aqueous extract aqueous (VVAE) extract was carried out to identify the phytoconstituents. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. During the experimental periods parameters like lipid profile, liver function test, atherogenic index and histopathological studies were analysed. Results: Total tannins, total flavonoids and total phenolic contents were found in major amount in VVME. The lipid levels were significantly attenuated by different doses of VVME and VVAE. Moreover, VVME was found more effective than VVAE and histopathological results confirmed the effectiveness of VVME. Conclusion: It can be concluded that anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of active phytoconstituents and its antioxidant efficacy.http://www.sciencedirect.com/science/article/pii/S2213453016301161Vitis viniferaHypercholesterolemiaCholesterol dietTotal phenolic content |
| spellingShingle | Sushma Devi Randhir Singh Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves Food Science and Human Wellness Vitis vinifera Hypercholesterolemia Cholesterol diet Total phenolic content |
| title | Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves |
| title_full | Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves |
| title_fullStr | Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves |
| title_full_unstemmed | Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves |
| title_short | Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves |
| title_sort | evaluation of antioxidant and anti hypercholesterolemic potential of vitis vinifera leaves |
| topic | Vitis vinifera Hypercholesterolemia Cholesterol diet Total phenolic content |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016301161 |
| work_keys_str_mv | AT sushmadevi evaluationofantioxidantandantihypercholesterolemicpotentialofvitisviniferaleaves AT randhirsingh evaluationofantioxidantandantihypercholesterolemicpotentialofvitisviniferaleaves |