Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta)
ABSTRACT Squamous cell carcinoma (SCC) has a high incidence in non‐human primates (NHPs), which affects animal health and causes huge losses to the experimental monkey breeding industry. In this case, gastroscope showed a smooth‐surfaced elevated lesion located approximately 18 cm from the incisor t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.70266 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850098539983536128 |
|---|---|
| author | Heling Li Lixian Chen Long Zhang Xinglong Chen Hong Wang |
| author_facet | Heling Li Lixian Chen Long Zhang Xinglong Chen Hong Wang |
| author_sort | Heling Li |
| collection | DOAJ |
| description | ABSTRACT Squamous cell carcinoma (SCC) has a high incidence in non‐human primates (NHPs), which affects animal health and causes huge losses to the experimental monkey breeding industry. In this case, gastroscope showed a smooth‐surfaced elevated lesion located approximately 18 cm from the incisor teeth of the diseased rhesus monkey. Computed tomography (CT) showed a space‐occupying lesion in the oesophagus. Haematoxylin & eosin (HE) staining revealed an invasive tumour of polygonal nests in the submucosa and muscularis, while keratosis and nuclear atypia were also observed. Immunohistochemistry (IHC) studies revealed tumour cells positive for p63, CK5/6, p40, CK20, CK7 and CK19. Based on imaging and pathology findings, the rhesus monkey was diagnosed as oesophageal squamous cell carcinoma (ESCC) and was treated surgically. Unfortunately, the rhesus monkey was euthanized eventually according to its poor health condition. This provides an important reference for the diagnosis and treatment of ESCC in rhesus monkeys, and also provides an important spontaneous animal model for future research on ESCC. |
| format | Article |
| id | doaj-art-1531ce6ffbab460687cc8b94fc42c270 |
| institution | DOAJ |
| issn | 2053-1095 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj-art-1531ce6ffbab460687cc8b94fc42c2702025-08-20T02:40:42ZengWileyVeterinary Medicine and Science2053-10952025-03-01112n/an/a10.1002/vms3.70266Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta)Heling Li0Lixian Chen1Long Zhang2Xinglong Chen3Hong Wang4State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming Yunnan ChinaKunming Biomed International Ltd. Kunming Yunnan ChinaKunming Biomed International Ltd. Kunming Yunnan ChinaState Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming Yunnan ChinaState Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming Yunnan ChinaABSTRACT Squamous cell carcinoma (SCC) has a high incidence in non‐human primates (NHPs), which affects animal health and causes huge losses to the experimental monkey breeding industry. In this case, gastroscope showed a smooth‐surfaced elevated lesion located approximately 18 cm from the incisor teeth of the diseased rhesus monkey. Computed tomography (CT) showed a space‐occupying lesion in the oesophagus. Haematoxylin & eosin (HE) staining revealed an invasive tumour of polygonal nests in the submucosa and muscularis, while keratosis and nuclear atypia were also observed. Immunohistochemistry (IHC) studies revealed tumour cells positive for p63, CK5/6, p40, CK20, CK7 and CK19. Based on imaging and pathology findings, the rhesus monkey was diagnosed as oesophageal squamous cell carcinoma (ESCC) and was treated surgically. Unfortunately, the rhesus monkey was euthanized eventually according to its poor health condition. This provides an important reference for the diagnosis and treatment of ESCC in rhesus monkeys, and also provides an important spontaneous animal model for future research on ESCC.https://doi.org/10.1002/vms3.70266oesophageal squamous cell carcinomaimaging examinationimmunohistochemistryrhesus monkey |
| spellingShingle | Heling Li Lixian Chen Long Zhang Xinglong Chen Hong Wang Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta) Veterinary Medicine and Science oesophageal squamous cell carcinoma imaging examination immunohistochemistry rhesus monkey |
| title | Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta) |
| title_full | Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta) |
| title_fullStr | Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta) |
| title_full_unstemmed | Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta) |
| title_short | Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (Macaca mulatta) |
| title_sort | imaging and pathological comprehensive analysis of oesophageal squamous cell carcinoma in a rhesus monkey macaca mulatta |
| topic | oesophageal squamous cell carcinoma imaging examination immunohistochemistry rhesus monkey |
| url | https://doi.org/10.1002/vms3.70266 |
| work_keys_str_mv | AT helingli imagingandpathologicalcomprehensiveanalysisofoesophagealsquamouscellcarcinomainarhesusmonkeymacacamulatta AT lixianchen imagingandpathologicalcomprehensiveanalysisofoesophagealsquamouscellcarcinomainarhesusmonkeymacacamulatta AT longzhang imagingandpathologicalcomprehensiveanalysisofoesophagealsquamouscellcarcinomainarhesusmonkeymacacamulatta AT xinglongchen imagingandpathologicalcomprehensiveanalysisofoesophagealsquamouscellcarcinomainarhesusmonkeymacacamulatta AT hongwang imagingandpathologicalcomprehensiveanalysisofoesophagealsquamouscellcarcinomainarhesusmonkeymacacamulatta |