Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet
Blackcurrant (BC) extract was reported to exert anti-obesity effects. However, it is unknown whether BC extract with a composition close to the totum differentially affects obesity when compared to one of its active compounds. We evaluated the anti-obesity effects of a BC standardized hydro-alcoholi...
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2024-12-01
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| author | Gwendoline Bréger Agnès André César Cotte Abderrahim Hammaidi Aline Amérand Claude Faivre Lionel Martignat Mohamed Yassine Mallem |
| author_facet | Gwendoline Bréger Agnès André César Cotte Abderrahim Hammaidi Aline Amérand Claude Faivre Lionel Martignat Mohamed Yassine Mallem |
| author_sort | Gwendoline Bréger |
| collection | DOAJ |
| description | Blackcurrant (BC) extract was reported to exert anti-obesity effects. However, it is unknown whether BC extract with a composition close to the totum differentially affects obesity when compared to one of its active compounds. We evaluated the anti-obesity effects of a BC standardized hydro-alcoholic leaf extract (BC-HLE) in an HFD-induced obesity rat model and compared them with quercetin (QUE). Thirty-six 12-week-old Wistar rats were divided into six groups: control, HFD, BC-HLE- (41 and 50 mg/kg) and QUE- (0.9 and 50 mg/kg) supplemented HFD rats for 12 weeks. HFD rats developed a moderate obesity, associated with a gut dysbiosis and a change in their total antioxidant capacity. The increase in body weight gain was prevented only by the low dose of BC-HLE and the high dose of QUE. The impaired glucose tolerance by HFD was attenuated by the low dose of QUE. Hepatic glutathione peroxidase activity was increased in the HFD group and only BC-HLE supplementation counteracted this change. The low BC-HLE dose tended to reduce the HFD-induced gut dysbiosis. These findings suggest that while QUE has beneficial effects on obesity-related disorders, the BC-HLE may offer even greater overall benefits and could contribute to preventing obesity and related conditions. |
| format | Article |
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| institution | OA Journals |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-1529bf3bcf19479a916aed0bd396462e2025-08-20T02:01:06ZengMDPI AGBiology2079-77372024-12-01131299910.3390/biology13120999Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat DietGwendoline Bréger0Agnès André1César Cotte2Abderrahim Hammaidi3Aline Amérand4Claude Faivre5Lionel Martignat6Mohamed Yassine Mallem7Oniris, Nutrition, Pathophysiology and Pharmacology (NP3), 101 route de Gachet, 44307 Nantes CEDEX 3, FranceOniris, Nutrition, Pathophysiology and Pharmacology (NP3), 101 route de Gachet, 44307 Nantes CEDEX 3, FranceNaturopôle Nutrition Santé, PiLeJe Industrie, Les Tiolans, 03220 Saint Bonnet-de-Rochefort, FranceWamine Industrie, 1 ZI duTaillis, Champtoceaux, 49270 Orée d’Anjou, FranceOrphy EA 4324, University of Brest, 6 avenue Victor Le Gorgeu, 29238 Brest, FranceWamine Industrie, 1 ZI duTaillis, Champtoceaux, 49270 Orée d’Anjou, FranceOniris, Nutrition, Pathophysiology and Pharmacology (NP3), 101 route de Gachet, 44307 Nantes CEDEX 3, FranceOniris, Nutrition, Pathophysiology and Pharmacology (NP3), 101 route de Gachet, 44307 Nantes CEDEX 3, FranceBlackcurrant (BC) extract was reported to exert anti-obesity effects. However, it is unknown whether BC extract with a composition close to the totum differentially affects obesity when compared to one of its active compounds. We evaluated the anti-obesity effects of a BC standardized hydro-alcoholic leaf extract (BC-HLE) in an HFD-induced obesity rat model and compared them with quercetin (QUE). Thirty-six 12-week-old Wistar rats were divided into six groups: control, HFD, BC-HLE- (41 and 50 mg/kg) and QUE- (0.9 and 50 mg/kg) supplemented HFD rats for 12 weeks. HFD rats developed a moderate obesity, associated with a gut dysbiosis and a change in their total antioxidant capacity. The increase in body weight gain was prevented only by the low dose of BC-HLE and the high dose of QUE. The impaired glucose tolerance by HFD was attenuated by the low dose of QUE. Hepatic glutathione peroxidase activity was increased in the HFD group and only BC-HLE supplementation counteracted this change. The low BC-HLE dose tended to reduce the HFD-induced gut dysbiosis. These findings suggest that while QUE has beneficial effects on obesity-related disorders, the BC-HLE may offer even greater overall benefits and could contribute to preventing obesity and related conditions.https://www.mdpi.com/2079-7737/13/12/999blackcurrant (<i>Ribes nigrum</i>)quercetinpolyphenolsobesityrat |
| spellingShingle | Gwendoline Bréger Agnès André César Cotte Abderrahim Hammaidi Aline Amérand Claude Faivre Lionel Martignat Mohamed Yassine Mallem Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet Biology blackcurrant (<i>Ribes nigrum</i>) quercetin polyphenols obesity rat |
| title | Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet |
| title_full | Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet |
| title_fullStr | Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet |
| title_full_unstemmed | Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet |
| title_short | Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet |
| title_sort | anti obesity effects evaluation of a blackcurrant leaf standardized hydro alcoholic extract in wistar rat subjected to a high fat diet |
| topic | blackcurrant (<i>Ribes nigrum</i>) quercetin polyphenols obesity rat |
| url | https://www.mdpi.com/2079-7737/13/12/999 |
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