Effector Tc17 cells resist shift from OXPHOS to aerobic glycolysis

Effector Tc17 cells resist shift from OXPHOS to aerobic glycolysis

IL-17A-expressing lymphocytes, including Tc17 cells, are instrumental in immunity, immunopathology, and autoimmunity. We have previously shown that experimental attenuated live fungal vaccine-induced Tc17 cells are stable, long-lived without plasticity, and necessary to mediate sterilizing immunity...

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Bibliographic Details
Main Authors: Reni John, Srinivasu Mudalagiriyappa, Nagabhushan Chandrashekar, Som G. Nanjappa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cell
Tc17 cell
glycolysis
OXPHOS
T cell activation
antifungal
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571221/full
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